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Parveen Shahida Akhtar
P3.01 - Advanced NSCLC (Not CME Accredited Session) (ID 967)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Presentations: 1
- Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
P3.01-116 - Randomized Clinical Trial on Three Different Platinum Based Chemotherapy in Advanced NSCLC in Bangladeshi Population (ID 12413)
12:00 - 13:30 | Author(s): Parveen Shahida Akhtar
Lung cancer constitutes the major mortality in the world and incidence of the disease varies considerably among different ethnic population throughout the world. Palliative chemotherapy has been a choice in advance Non-Small Cell Lung Cancer (NSCLC) due to better result. The primary objective of the study was to evaluate the response and toxicity of three different platinum based regimens in Bangladeshi people.a9ded1e5ce5d75814730bb4caaf49419 Method
This Randomized Clinical Trial (RCT) was carried out in the Department of Medical Oncology at National Institute of Cancer Research & Hospital (NICRH), Mohakhali, Dhaka. Patients were enrolled from January 2012 for one year. Total 90 patients with above 18 years of age, both sexes presented with histologically confirmed stage IIIA, IIIB & IV NSCLC were enrolled and randomized (1:1:1) in to three arms. Cumulatively 26 patients were lost to follow up.
Chemotherapy was given in 21 days interval (4-6 cycles). Toxicities were measured on Day 1, 7, 21, 28, 42, 3 months and on 6 months. Median follow up period was 6 months. Survival data was estimated by Kaplan-Meier method.4c3880bb027f159e801041b1021e88e8 Result
Significant G-1/2 Hb% was found in Day7 in TP (16.67%) and EP (10.52%) arm and in 6 months EP (31.58%) & TP (29.17%). WBC G-1/2 toxicity was found in EP (31.58%) & TP (20.83%) arm at 6 months. Similarly, in case of neutropenia and thrombocytopenia, GP arm was found to be significantly less toxic than TP and EP arm at 6 months. Response rate and survival data are provided in table 1.
In locally advanced or metastatic NSCLC response rate of platinum based combination therapy was satisfactory with increased survival than other reference trials along with lower G1/2 toxicity in GP arm followed by TP and EP in Bangladeshi Ethnic population.6f8b794f3246b0c1e1780bb4d4d5dc53
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