Author of

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  P3.CR - Case Reports (Not CME Accredited Session) (ID 984)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27851

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    P3.CR-32 - Amyloid Deposition in Thymic Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue: A Case Report (ID 13614)

    12:00 - 13:30  |  Presenting Author(s): Kyung Joo Park
    • Abstract
    • Slides

    Background
    

    Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) is a rare thymic tumor with a few cases described to date. Amyloid deposition can be unusually associated with MALT lymphoma, and those cases have been reported arising from the lung, soft tissue, ocular adnexa, skin, and aerodigestive tract. To our knowledge, our case is the first report of thymic MALT lymphoma with amyloid deposition.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A 35-year-old East Asian male presented with dyspnea on exertion. He did not have any history of autoimmune disease. His CT scan showed a 7.5-cm mass in the anterior mediastinum with extensive conglomerated calcification (Fig 1a and b). Acetylcholine receptor antibody titer was elevated up to 7.83 nmol/L. The mass was removed by median sternotomy and histologically diagnosed as extranodal marginal zone lymphoma of MALT arising from the thymus. Extensive amyloid deposition was noted within the tumor with a positive stain to Congo red, apple-green birefringence on polarized microscopy and binding of antibodies predominantly to kappa light chain.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Section not applicable

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    We report a case of thymic MALT lymphoma with extensive amyloid deposition. Unusual CT manifestation of extensive calcification can lead to difficulties in differential diagnosis of mediastinal masses.

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