Start Your Search
P3.CR - Case Reports (Not CME Accredited Session) (ID 984)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Presentations: 1
- Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
P3.CR-18 - Central Nervous System Activity of Checkpoint Inihibitor in Non-Small-Cell Lung Cancer (ID 14148)
12:00 - 13:30 | Author(s): Taiane Rebelatto
Data regarding the activity of atezolizumab in the central nervous system (CNS) and its toxicity in combination with radiotherapy in patients with brain metastases (BM) of non-small cell lung cancer (NSCLC) is limited. Most clinical trials adopt strict selection criteria excluding patients with active BM and the blood–brain barrier (BBB) seems responsible for limiting the distribution of agents into the CNS.a9ded1e5ce5d75814730bb4caaf49419 Method
Here we present a 51 yr-old female patient with the diagnosis of stage IV NSCLC with an isolated BM (T3 N3 M1b, non-mutated EGFR). She received stereotactic radiosurgery (SRS) to the isolated brain lesion (figure 1) and sequential palliative first-line systemic monotherapy with atezolizumab (1200mg/dose q21d, 15 doses).
Control brain MRI 3-month post SRS showed a new lesion in the thalamus (figure 2) while on atezolizumab. Medical team decided to continue systemic treatment and the repeat brain MRI demonstrated complete response to the new lesion. Additionally, treated lesion showed evidence of pseudoprogression. While on follow-up, the patient continued to respond in the brain for 14 months.
This case reports activity of atezolizumab in CNS. The advent of immunotherapy in the therapeutic algorithm of NSCLC has raised the need to identify patients that could mostly benefit from checkpoint inhibitors.6f8b794f3246b0c1e1780bb4d4d5dc53
Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.