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Biao Wu
Author of
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P3.CR - Case Reports (Not CME Accredited Session) (ID 984)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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P3.CR-12 - A Novel Oncogenic Driver in a Lung Adenocarcinoma Patient Harboring an EGFR-KDD and Response to Afatinib (ID 11273)
12:00 - 13:30 | Author(s): Biao Wu
- Abstract
Background
Oncogenic mutations in the epidermal growth factor receptor (EGFR) are found in a subset of patients with non-small cell lung cancer (NSCLC) and serve as important predictive biomarkers in this disease. EGFR exon 18-25 kinase domain duplication (EGFR-KDD) mutations has rencently emerged as a new EGFR gene molecular subtype in non-small cell lung cancer(NSCLC) is extremely rare.
a9ded1e5ce5d75814730bb4caaf49419 Method
A 59-year-old male diagnosed with adenocarcinoma, who was shown to have gene detected by the next generation sequencing (NGS)and treatment with afatinib.
4c3880bb027f159e801041b1021e88e8 Result
Histopathological observations with hematoxylin and eosin staining was shown adenocarcinoma, immunohistochemical staining for the expression of TTF-1, NapsinA and CK7. The gene detected by NGS that found an EGFR-KDD, CTNNB1 p.S37Y and TP53 p.R282W. Our case is the second report EGFR-KDD in Chinese populations. The patient was treated with afatinib therapy. And afatinib therapy showed a good response.
8eea62084ca7e541d918e823422bd82e Conclusion
The cases presented here highlight that adjusting our strategy and using newly available tools, such as comprehensive NGS tests, could prove useful in detecting alternative ways in which the EGFR pathway is altered (and can be targeted) in tumors.
6f8b794f3246b0c1e1780bb4d4d5dc53
