Virtual Library

Start Your Search

Marco Lucchi

Author of

  • +

    P3.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 982)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
    • +

      P3.16-39 - Which Surgery for Ground Glass Opacity Lung Nodules? (ID 13527)

      12:00 - 13:30  |  Author(s): Marco Lucchi

      • Abstract
      • Slides


      Pulmonary ground glass opacity (GGO) nodules represent a significant dilemma in oncology since its diagnosis in clinical practice has increased because of growing application of low dose computed tomography and screening programme. The aim of this study is to analyse the clinical and pathological features, the overall survival (OS) and Disease Free Interval (DFI) in surgically resected solitary ground glass nodules in order to assess the surgical treatment of choice.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We retrospectively analysed 49 patients (M/F=25/24) with a mean age of 67,7 years (range 40-81) who underwent lung resection for solitary GGO nodules among 570 reviewed CT of patients treated for lung neoplasms between 2010 and 2016. The cohort included 22 pure GGO nodules and 27 part-solid GGOs (also called mixed GGOs).

      4c3880bb027f159e801041b1021e88e8 Result

      Median maximum diameter of GGOs, defined as the largest axial diameter of the lesion on the lung-window setting, was 17 mm (range,5–30). GGO nodules were removed by wedge resection, segmentectomy, or lobectomy in 17 (35%), 9 (18%), and 23 (47%) cases, respectively. Pathology showed minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IA) or multifocal adenocarcinoma (MAC) in 9 (18%), 37 (76%) and 3 (6%) cases, respectively. With a median follow up of 47 months the OS and DFI of the entire cohort was 46,3 and 43 months respectively. The histotype (p=0,008), the size of GGO (p=0,014) and the PET-SUV max (p=0,001) were independent prognostic factors of worse survival. Sex, age, previous lung surgery, type of surgical resection and the mediastinal lymph-node evaluation did not impact on OS and DFI. Analysing the 22 pure GGO nodules, we found a 3-year OS and DFI of 98% and 100% respectively, significantly different from 80% and 75% respectively of part-solid GGOs (log-rank p=0,043 and p=0,011).

      8eea62084ca7e541d918e823422bd82e Conclusion

      Our data suggest an indolent behaviour of tumours presenting as solitary GGO nodules, especially in case of pure GGOs. In our series wedge resections guarantee the same results in terms of OS and DFI when compared to lobectomies. Sublobar resections without mediastinal lymph-nodes evaluation represent the treatment of choice for pure-GGO. More studies are needed to assess its role for part–solid GGO nodules.


      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.