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  P3.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 982)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27774

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    P3.16-32 - A Study of Postoperative Recurrence in Pathological Stage 1 Non-Small Cell Lung Cancer Patients (ID 12663)

    12:00 - 13:30  |  Author(s): Hiroyoshi Maeda
    • Abstract
    • Slides

    Background
    

    Even in pathological stage 1 non-small cell lung cancer, there are some cases in which recurrence occurs after surgical treatment. The prognosis of the recurrent cases is poor despite the early stage of their disease. An analysis of the clinicopathological factors of these recurrent cases may help improve the prognosis.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 199 patients underwent surgical treatment for primary lung cancer from July 2010 to December 2017 in our hospital. We retrospectively analyzed the clinicopathological factors of 131 patients (65.8%) with pathological stage 1 disease. To compare the clinical data, we divided the 131 patients into 2 groups depending on the presence of recurrence. Group A was recurrent cases and group B nonrecurrent cases. For the statistical analysis, the T-test, F-test, and chi-squared test were used.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Group A included 19 cases and group B 112 cases. The mean age was 71.3±5.4 years in group A and 70.7 ± 8.0 years in group B (p = 0.75). The procedures performed in group A were lobectomy in 14, segmentectomy in 2, and wedge resection in 3, while those performed in group B were lobectomy in 83, segmentectomy in 18, and wedge resection in 11 (p=0.13). The mean tumor size was 2.5±0.9 cm in group A and 2.0±0.9 cm in group B (p<0.05). In group A, pathologic T factor 1a was found in 0 patients, 1b in 3, 1c in 6, and 2a in 10. In group B, 1a was found in 17 patients, 1b in 48, 1c in 23, and 2a in 24 (p＜0.05). Pleural invasion (pl) in group A was 0 in 13 patients, 1 in 6, and 2 in 0, while that in group B was 0 in 99 patients, 1 in 11, and 2 in 2 (p=0.56). Positive lymphatic invasion (ly+) and venous invasion (v+) were found in 6 and 10 patients in group A and 14 and 17 patients in group B, respectively (p＜0.05, p＜0.01). The mean survival time after the operation was 1185.8±557.0 days in group A and 1034.3±736.0 days in group B (p=0.39).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    The mean tumor size and pT outcomes showed significant differences between the two groups. Furthermore, ly and v were positive significantly more frequently in the postoperative recurrence group. In conclusion, the tumor size, ly+, and v+ indicate a high malignant potential and may be considered predictors of a poor prognosis in patients with early-stage lung carcinoma.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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