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Carlos Vallejos



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    P3.15 - Treatment in the Real World - Support, Survivorship, Systems Research (Not CME Accredited Session) (ID 981)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 2
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.15-10 - Survival Impact of Peripheral Blood Ratios in Lung Cancer According Clinical Stage (ID 14061)

      12:00 - 13:30  |  Author(s): Carlos Vallejos

      • Abstract
      • Slides

      Background

      Lung cancer represents one of the most frequent and letal neoplasms in many regions, where most patients are still diagnosed as advanced disease, and many biomarkers have been studied unsuccessfully. Peripheral blood ratios as Neutrophil-to-lymphocyte ratio (NLR), Monocyte-to-lymphocyte ratio (MLR) and Platelets-to-lymphocyte ratio (PLR) have been studied as potential biomarkers of systemic inflammation but cut-off values are still difficult to stablish. We explored the survival impact of different cut-off values according clinical stages in lung cancer.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We analyzed medical records of 193 patients with lung cancer treated at ONCOSALUD–AUNA 2011-2014. Peripheral blood data was obtained retrospectively from the first medical visit and we calculated optimal cut-off values using the maximally selected rank statistics according every clinical stage (CS). Overall survival (OS) was evaluated using Kaplan-Meier method and survival curves comparison was performed using log-rank test or Breslow.

      4c3880bb027f159e801041b1021e88e8 Result

      Median age was 67 years (range: 34-88), 51% were women and 71.5% had 0-1 ECOG scale. The 9.8, 11.4, 18 and 60% were CS I, II, III and IV. The most common metastatic sites were brain, bones, cervical and supraclavicular nodes. Patients with I CS underwent to lobectomy, and 59% of II and most III-IV CS received chemotherapy. The median follow-up was 4.9years, median OS was 1.4years (95%CI: 1.1-1.9) and 2 and 5years OS were 42% and 25%, respectively. The next table shows survival impact of blood ratios according CS. Optimal cut-off values were different according every CS of lung cancer, however in the IV CS group the cut-off of 2.6 and 0.31 for NLR and MLR showed significant survival impact on OS.

      table.png

      8eea62084ca7e541d918e823422bd82e Conclusion

      Our results suggest that exists different cut-off values for blood ratios according every clinical stage that needs to be explored among larger population data-bases to confirm it. In advanced disease, NLR and MLR show significant survival impact in this study.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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      P3.15-11 - Association Between Peripheral Blood Ratios and Clinical Stage Disease in Lung Cancer. (ID 14312)

      12:00 - 13:30  |  Author(s): Carlos Vallejos

      • Abstract
      • Slides

      Background

      Many attempts have been described to stablish peripheral blood ratios as systemic immune biomarkers in lung cancer, unfortunately they are not still considered because of lack accuracy and sensibility. In this study, we explore and correlate clinical stages to median values of peripheral blood ratios as Neutrophil-to-lymphocyte ratio (NLR), Monocyte-to-lymphocyte ratio (MLR) and Platelets-to-lymphocyte ratio (PLR) among patients with lung cancer.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Retrospectively, we review clinical and laboratory data from 193 patients with lung cancer treated at Oncosalud – AUNA from 2011 to 2014. The laboratory data (hemoglobin, leukocytes, neutrophil, lymphocyte and monocyte) were collected from blood routine test obtained from the first clinic visit. The median (range) and mean (± SD) of the ratios were determined according every clinical stage and compared using the U Mann Whitney test.

      4c3880bb027f159e801041b1021e88e8 Result

      Median age was 67 years, and 63 (34-79), 64 (37-83), 69 (44-88) and 67 (38-86) years in I, II, III and IV CS, respectively. In early disease (I-II), female patients were slightly more frequent that men. Median hemoglobin was 13.6, 12.4, 13 and 12.7 gr/dl for I, II, III and IV CS, respectively. Peripheral blood levels (leukocytes, lymphocytes, monocytes and platelets) show a slightly higher level among patients with advanced disease. Median NLR, MLR and PLR are described in the following table, there was a significant difference between early and advanced disease (III and IV CS) for NLR and MLR.

      table 2.png

      8eea62084ca7e541d918e823422bd82e Conclusion

      These results suggest that there are higher levels of peripheral blood ratios related to advanced disease; but larger studies are needed to confirm it. Only NLR and MLR showed differences between early and advanced disease.

      6f8b794f3246b0c1e1780bb4d4d5dc53

      Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.