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Francis Cheung



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    P3.15 - Treatment in the Real World - Support, Survivorship, Systems Research (Not CME Accredited Session) (ID 981)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.15-01 - Long-Term Outcomes of Pulmonary Metastasectomy: A 12-Year Dual Centre Experience (ID 13176)

      12:00 - 13:30  |  Author(s): Francis Cheung

      • Abstract
      • Slides

      Background

      Pulmonary metastases are a common site of spread for many cancers. We describe the long-term outcomes of surgical resection of pulmonary metastases at two major cancer centres.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The study institutions thoracic surgery databases were searched for all patients who underwent pulmonary metastasectomy between 2005 and 2017.

      4c3880bb027f159e801041b1021e88e8 Result

      There were a total of 489 patients who underwent pulmonary metastasectomy. Mean age at time of surgery was 45.6 ± 11.6 years. There were a total of 658 operations performed with 105 (21.5%) patients having repeat pulmonary metastasectomy. Of these patients 68 (64.8%) had 1 repeat operation, 20 (19.0%) had 2 repeat operations, 11 (10.5%) had 3 repeat operations, 2 (1.9%) had 4 repeat operations and 4 (3.8%) had 5 repeat operations.

      The most common primary lesions were colorectal cancer (CRC) in 35.3% (173/489) of patients, sarcoma in 23.7% (116/489) of patients, melanoma in 16.2% (79/489) patients, renal cell carcinoma (RCC) in 7.2% (35/489) of patients and germ cell carcinoma (GCC) in 4.5% (22/489) of patients. Other cancers accounted for the remaining 13.1% (64/489) of patients.

      Mean follow-up was 41.2 ± 1.6 months and was complete for 91.8% of patients. Survival was 85.6% (95%CI: 81.9 – 88.9%) at 1-year, 45.2% (95%CI: 39.7 – 50.5%) at 5-years and 27.8 (95%CI: 21.2 – 34.6%) at 10-years follow-up (figure 1). On univariate Cox regression analysis CRC (p = 0.027) and GCC (p = 0.016) were associated with improved survival while melanoma (p = 0.039) was a risk factor for mortality. On multivariate Cox regression analysis CRC (p = 0.025) and GCC (p = 0.011) were associated with improved survival.
      pulmonary mets kaplan-meier 300dpi.jpg

      8eea62084ca7e541d918e823422bd82e Conclusion

      Pulmonary metastasis is associated with survival of less than 30% at 10 years follow-up. CRC and GCC cancers were associated with better long-term mortality while melanoma was associated with worse long-term mortality.

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