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Kristina Viktorsson



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    P3.12 - Small Cell Lung Cancer/NET (Not CME Accredited Session) (ID 978)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.12-17 - A Retrospective Study Examining the Role of PET-CT in the 8<sup>th</sup> TNM Staging System of SCLC (ID 12873)

      12:00 - 13:30  |  Author(s): Kristina Viktorsson

      • Abstract
      • Slides

      Background

      We have recently performed a validation of the 8th TNM system in SCLC. The aim of the present study is to perform a subgroup analysis on patients (pts) who underwent a PET/CT scan, to furhter assess potential utility of this method in SCLC pts, since PET/CT is usually performed primarily to identify potentially curable cases.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Between January 2008 and February 2016, a total of 706 pts with SCLC were diagnosed in the Stockholm and Gotland region. A multivariate model adjusted for basic patient characteristics and PET-CT was performed.

      4c3880bb027f159e801041b1021e88e8 Result

      One third of the patients had performed a PET/CT scan (n=204). Pts were classified according to the 8th TNM. The table shows patient distrubution according to clinical variables and stage (8th TNM), as well as HR for multivariate survival analysis. Many pts (48%) were classified to stage I-III disease, while the rest had stage IV. Pts with stage I-III were treated with Surgery (n=13), Radiotherapy+ Chemotherapy (CT) (n=80) or Stereotactic body radiation (n=7). The patients who were diagnosed with stage IV disease were treated with palliative CT or did not receive any oncological therapy. In pts that did not perform PET/CT, the majority (87%) were treated with CT or did not receive treatment. The percentage of pts diagnosed with M1b-disease was slighlty higher in those who performed a PET/CT vs those who did not (7% vs 3%, respectivley).

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      8eea62084ca7e541d918e823422bd82e Conclusion

      The 8th TNM edition has a strong prognostic impact in SCLC. Incorporating a PET/CT scan in the diagnostic workup of SCLC is relevant to distinguish potentially curable pts (stages I-III) from pts with stage IV disease, and may be of value to indentify single extra-thoracic metastases (M1b cases).

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