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Dan Liu



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    P3.11 - Screening and Early Detection (Not CME Accredited Session) (ID 977)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.11-27 - Lung Cancer Diagnosed at Age 50-54 Years: Survival as Poor as Older Patients (ID 14233)

      12:00 - 13:30  |  Author(s): Dan Liu

      • Abstract

      Background

      The United States Preventive Services Task Force (USPSTF) recommends lung cancer screening with low-dose computed tomography among people aged 55-80 years with a 30 pack-year cigarette smoking history and, if stopped smoking, quitted within 15 years. We previously identified a prominent subpopulation that would have been too young (i.e., 50-54.9 years) yet otherwise met the USPSTF criteria and were diagnosed with lung cancer. We assessed survival outcomes in these younger patients compared to those eligible for USPSTF lung cancer screening.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We studied two cohorts of 7,390 primary lung cancer patients: a Hospital Cohort from Mayo Clinic Rochester (n=6,554) and a Community Cohort from the Olmsted County population (n=836, Minnesota, USA). All patients were diagnosed between age 50 and 80 years, had >30 pack-year smoking history and had quitted <15 years if they had stopped smoking. Two cohorts were analyzed independently to evaluate the impact of younger age (50-54.9 years) on overall survival using Cox Proportional Hazard models by hazard ratio (HR) and 95% confidence interval (CI). Known prognostic factors (age, sex, tumor stage and treatment) were adjusted. To control for age gap, the USPSTF group was subdivided into a 55–69 age subgroup (lower age USPSTF subgroup) and a 70–80 age subgroup (higher age USPSTF subgroup).

      4c3880bb027f159e801041b1021e88e8 Result

      In both cohorts, the younger age group had at least the same risk of death as patients who met the USPSTF criteria; HR=1.16 for both cohorts; p=0.08 for the Hospital Cohort and p=0.52 for the Community Cohort. Age-group stratified analyses did not change the results in either cohort.

      8eea62084ca7e541d918e823422bd82e Conclusion

      People who are 50-54.9 years of age and otherwise meet the USPSTF screening criteria for lung cancer, once diagnosed, experience a similar or potentially worse survival outcome as older patients. Benefit of screening in this younger population deserves consideration and futher study.

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