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Gilberto De Castro, Jr.



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    P3.09 - Pathology (Not CME Accredited Session) (ID 975)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.09-25 - Survival Analysis in Young Adults with Lung Carcinoma (ID 13839)

      12:00 - 13:30  |  Author(s): Gilberto De Castro, Jr.

      • Abstract
      • Slides

      Background

      Lung cancer is uncommon in young adults and there is no consensus about its behavior in this age group. The aim of this study was to compare clinical and pathological characteristics and median overall survival in young adults (≤ 40 years) and older adults (intermediate: 41-65 years and elderly: > 65 years) with lung carcinoma.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      A retrospective cohort study including information from 21,285 lung cancer cases (ICD – O: C34) diagnosed in the period 2000 – 2009 was performed. Cases were retrieved from the hospital based cancer registries in the state of Sao Paulo, Brazil. Study variables included sex, histological type, cancer staging based on the TNM System, status in the last follow-up, date of diagnosis and date of death. For 1,410 patients, who were initially considered lost to follow-up, a consultation was made through Brazilian databases, such as national registry of deceased, registry of living individuals and voting status in political elections (Brazilian compulsory voting system). After this search, 202 patients remained as loss of follow-up (1.02%). Survival analysis was performed by Kaplan-Meier curve and log-rank tests.

      4c3880bb027f159e801041b1021e88e8 Result

      Among 21,285 patients, 19,900 were further analyzed, after exclusion of patients diagnosed with malignant neoplasms without specification, carcinoid and neuroendocrine tumors and in situ carcinomas. Most patients were diagnosed with adenocarcinoma (49.55%) or squamous cell carcinoma (27.67%) in advanced stage (clinical stages III and IV) (80.26%). Young adults were 542 patients (2.72%), intermediate adults were 10,661 (53.57%) and elderly people were 8,697 (43.70%). Adenocarcinoma was the most prevalent histological type in all age groups (63.09%, young adults vs 49.85%, intermediate adults vs 48.33%, elderly patients) and squamous cell carcinoma was the second most prevalent (14.02%, young adults vs 25.71%, intermediate adults vs 30.93%, elderly patients). In all age groups, most patients presented metastatic disease (stage IV: 58.85%, young vs 51.19%, intermediate vs 43.14%, elder adults). Median overall survival was significantly different among age groups: young adults, 9 months (CI 95%: 7.71-10.28); intermediate adults, 8 months (CI 95%: 7.74-8.25) and elder patients, 7 months (CI: 95%: 6.73-7.26)(p<0.001).

      8eea62084ca7e541d918e823422bd82e Conclusion

      Most young adults were diagnosed with adenocarcinoma in advanced stage. Although still very troublesome, our results indicated median overall survival was longer in young adults than in older adults.

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