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  P3.08 - Oligometastatic NSCLC (Not CME Accredited Session) (ID 974)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27569

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    P3.08-14 - Long-Term Survival Following Surgical Resection of Isolated Brain Metastasis in Non-Small Cell Lung Cancer. (ID 12890)

    12:00 - 13:30  |  Author(s): Chiate Yen
    • Abstract
    • Slides

    Background
    

    Lung cancer is one of the leading causes of death all over the world and the prevalence is still growing. About half of the patients are diagnosed with stage IV disease at presentation with the most common sites of distal metastasis including the brain, liver, adrenal glands, and bones. Brain metastases remain a significant problem in patients with lung cancer. Surgical resection of metastasis limited to brain had been recommended by guidelines. However, few patients received metastasectomy of brain metastasis and the benefit of such intervention is unclear. So, we reviewed such patients of a medical center to see if those patients achieved long term survival after operation.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    All patients of non-small cell lung cancer with brain metastasis diagnosed in 2011/1/1 to 2017/12/31 from a medical center were reviewed. The characteristics of the patients, local control rate, survival time after diagnosis of brain metastasis, EGFR status and surgical complications were recorded. The survival rate was calculated using Kaplan-Meier model.

    4c3880bb027f159e801041b1021e88e8 Result
    

    We identified 276 patients diagnosed with non-small cell lung cancer with brain metastasis. Of these, 24 patients received metastasectomy of brain lesions. 22 of the 24 patients had distal metastasis limited to brain. 2 patients were excluded due to loss of follow up within one month after surgery. 20 patients were included in the analysis, of which 19 were adenocarcinoma, 1 was sarcomatoid carcinoma.16 of them had solitary brain metastasis, 2 with 2 lesions and 2 with 4 lesions. The average size of brain mass was 3.67cm (range 0.5cm to 7.4cm, standard deviation 1.78cm). To the date of our data collection (2018/4/30), 8 of them were dead, 4 were censored and 8 were still alive with regular follow up. The median survival after diagnosis of brain metastasis was 40.3 months. The 3 year and 5 year survival rate were 72% and 24% respectively. Recurrence of brain metastasis was documented in 2 patients only. One patient died 26 days after operation due to intracranial hemorrhage. No cognitive function impairment or wound infection leading to prolonged hospitalization was recorded after operation

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    For non-small cell lung cancer patient with isolated brain metastasis, surgical resection of brain metastasis is likely to lead to long term survival with acceptable risk. Randomized case control study is needed to determine the best treatment strategy for this group of patients.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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