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  P3.08 - Oligometastatic NSCLC (Not CME Accredited Session) (ID 974)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27564

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    P3.08-09 - Surgical Resection of Pulmonary Oligo-Recurrence of Non-Small Cell Lung Cancer (ID 12821)

    12:00 - 13:30  |  Author(s): Hiroyuki Ogawa
    • Abstract

    Background
    

    The concept of oligo-recurrence, which is theoretically curable by definitive local therapy, has been proposed in several cancers. But the efficacy of surgical resection for pulmonary oligo-recurrence of lung cancer is unclear. The aim of this study was to investigate the efficacy of surgical resection of pulmonary oligo-recurrence of non-small cell lung cancer (NSCLC).

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    We retrospectively analyzed the data on 21 patients who underwent lung resection for pulmonary oligo-recurrence in our institution, between 2000 and 2016. We evaluated independent risk factors for progression-free survival after pulmonary resection.

    4c3880bb027f159e801041b1021e88e8 Result
    

    There were 14 men and 7 women with median age of 71 years [interquartile range (IQR), 65-72]. The median follow-up time was 48.8 months [IQR, 17.2-69.2]. Previous therapies for NSCLC were pulmonary resections in 16 (76.2%) patients, stereotactic radiosurgery for brain metastasis in 2 (9.5%), chemoradiotherapy in 2 (9.5%) and chemotherapy (ALK-TKI) in 1 (4.8%). Median progression-free interval between previous therapy and pulmonary resection of oligo-recurrence was 28.0 months [IQR, 16.0-40.0]. Histopathology was adenocarcinoma in 18 (85.9%) patients, squamous cell carcinoma, adenosquamous carcinoma and large cell neuroendocrine carcinoma in 1 (4.7 %). Surgical procedures were wedge resection in 11 patients, segmentectomy in 3, lobectomy in 5 and pneumonectomy in 2. There were no perioperative deaths. Three-year overall survival and progression-free survival were 68.6% and 59.3%. Postoperative recurrence occurred in 8 (38.1%) patients (local; 4, distant; 2, local and distant; 4). Univariate analyses identified progression-free interval between previous therapy and pulmonary resection of oligo-recurrence as independent risk factor for progression-free survival after pulmonary resection.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Surgical resections of pulmonary oligo-recurrence of NSCLC are feasible and the postoperative survival is acceptable. But there are highly selective patients in our study, further study is needed for curative intent treatment.

    6f8b794f3246b0c1e1780bb4d4d5dc53