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Wen-Hu Hsu

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    P3.04 - Immunooncology (Not CME Accredited Session) (ID 970)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.04-06 - Prognostic Significance of Serum CXCL12 Level in Patients with Surgical Resected Lung Adenocarcinoma (ID 14430)

      12:00 - 13:30  |  Author(s): Wen-Hu Hsu

      • Abstract


      Lung cancer is the leading cause of cancer-related death in the world. Cytokines are a heterogeneous group of soluble small polypeptides or glycoproteins. The tumor microenvironment is rich in cytokines and other inflammatory mediators that influence immunosuppression, cancer cells growth, tissue remodeling and angiogenesis. In this study, we determined the prognostic value of selected cytokines or chemokines in patients with lung adenocarcinoma.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Sixty-three patients undergoing surgical resection for lung adenocarcinoma were enrolled in this study. A total of 63 serum samples from these patients were used for study. The levels of cytokines/chemokines in these serum samples were determined by cytometric bead array according to manufacture’s instruction. The following cytokines/chemokines have been examined, including interleukin-1b (IL-1b), IL-6, IL-8, IL-10, CXCL9, CXCL10, CXCL12, CCL19, CCL21, and CCL25.

      4c3880bb027f159e801041b1021e88e8 Result

      With a median follow-up time of 62.3 months (range, 0.7 to 94.1 months), the 5-year overall survival rate was 88.1%. To determine the expression of cytokines/chemokines in lung adenocarcinoma serum samples, cytometric bead array was performed in 63 lung adenocarcinoma serum samples. Univariate analysis indicated that stage II and III (vs. stage I) (P = 0.016) was a significant prognostic factor for worse overall survival. Poor differentiation (P = 0.062) and CXCL12 overexpression (P = 0.052) tended to be significant prognostic factors for worse overall survival. IL-1b, IL-6, IL-8, IL-10, CXCL9, CXCL10, CCL19, CCL21, and CCL25 were not significant prognostic factors for overall survival. The advanced stage (II and III vs. I) (hazard ratio [HR], 7.775; 95% confidence interval [CI], 1.243 to 48.618; P = 0.028), poor differentiation (HR, 7.995; 95% CI, 1.092 to 58.547; P = 0.041) and CXCL12 overexpression (HR, 7.307; 95% CI, 1.163 to 45.899; P = 0.034) were still significant prognostic factors for worse overall survival in multivariate analysis. Male sex (P = 0.007) was significantly associated with CXCL12 overexpression.

      8eea62084ca7e541d918e823422bd82e Conclusion

      CXCL12 overexpression was a significant prognostic factor for worse overall survival in patients with surgical resected lung adenocarcinoma. Male sex was significantly associated with CXCL12 overexpression. CXCL12 overexpression has the potential to be used as a predictor of worse outcome in lung adenocarcinoma patients after surgical resection.