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Chundong Gu



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    P3.03 - Biology (Not CME Accredited Session) (ID 969)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.03-23 - A Propensity Score Matching Cohort Study on Prognosis of the Diversity of MUC1 Expression in Patients with Lung Adenocarcinoma (ID 13107)

      12:00 - 13:30  |  Presenting Author(s): Chundong Gu

      • Abstract
      • Slides

      Background

      To probe the expression of MUC1 (Mucin-1) in lung adenocarcinoma tissues, and estimate the relationship between the expression level of MUC1 and prognosis or clinical pathological factors in patients with lung adenocarcinoma simultaneously, so as to establish personal therapeutic strategies and forecast prognosis.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      A retrospective analysis was originally conducted on 182 lung adenocarcinoma patients who underwent surgical resection collected from July 2007 and September 2010 at the First Affiliated Hospital of Dalian Medical University. None of the patients received neoadjuvant therapy. Each tumor was reevaluated according to the current adenocarcinoma classification based on HE stains. Additional immunohistochemical staining for MUC1(Mucin-1) was used in selected cases. Cox proportional hazard regression model was used for univariate analysis. The confounding parameters were compromised by propensity score matching (PSM).

      4c3880bb027f159e801041b1021e88e8 Result

      Among 182 patients with lung adenocarcinoma, 107 patients were MUC1 low expressed, 44 patients were MUC1 moderate expressed 33 patients were MUC1 high expressed. We found the expression of MUC1 was significantly different in gender (p=0.014), smoking history (p=0.009), T stage (p=0.019), N stage (p=0.015), clinical stage (p=0.024) and the WHO classification of tumors of the lung adenocarcinoma (p=0.002). But we found all above differences among groups were no significance after PSM. Lung adenocarcinoma patients with high MUC1 expression, poorly differentiated and high pTNM stage had early relapse than the other (P≤0.05), no matter took PSM.

      Univariate analysis of clinical pathologic factors on disease-free survival risk.

      Clinical Factor

      HR

      95%CI

      P value

      Gender

      male

      1.000

      fmale

      0.732

      0.437-1.226

      0.236

      Age

      ≤67

      1.000

      >67

      0.928

      0.562 -1.534

      0.772

      History of smoking

      Out

      1.000

      Without

      1.756

      0.981 -3.140

      0.058

      Tumor size

      ≤2cm

      1.000

      >2cm

      2.100

      1.067- 4.135

      0.032

      Differentiation

      Poor

      1.000

      Moderate

      10.929

      4.734- 25.232

      0.001

      Well

      3.151

      1.376- 7.218

      0.007

      T stage

      T1

      1.000

      T2

      1.483

      0.798- 2.757

      0.213

      T3

      3.831

      2.083- 7.048

      0.001

      N stage

      N0

      1.000

      N1

      2.247

      0.879- 5.744

      0.091

      N2

      3.506

      2.047- 6.006

      0.001

      TNM stage

      I

      1.000

      II

      2.310

      0.810- 6.591

      0.118

      III

      3.823

      2.272- 6.432

      0.001

      Pathological subgroups

      MIA

      1.000

      AP

      3.414

      1.146- 10.174

      0.028

      PA

      1.486

      0.600- 3.683

      0.392

      MPA

      2.245

      0.918- 5.494

      0.076

      SOP

      5.566

      1.116- 27.754

      0.036

      MU

      5.148

      0.617- 42.923

      0.130

      Lep

      0.748

      0.090- 6.210

      0.788

      MUC1 expression

      Low

      1.000

      Moderate

      1.235

      0.604- 2.527

      0.563

      High

      2.289

      1.318- 3.974

      0.003

      MUC1 expression (PSM)

      Low

      1.000

      Moderate

      1.289

      0.557- 2.985

      0.553

      High

      2.462

      1.142- 5.312

      0.022

      8eea62084ca7e541d918e823422bd82e Conclusion

      High expression of MUC1 can be a significant independent risk factors for predicting the prognosis of lung adenocarcinoma.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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