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Shigekuni Hosogi



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    P3.03 - Biology (Not CME Accredited Session) (ID 969)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.03-04 - Is the Ciliary Function of the Lesion Bronchus Maintained in Patients with Lung Cancer? (ID 13626)

      12:00 - 13:30  |  Author(s): Shigekuni Hosogi

      • Abstract
      • Slides

      Background

      In patients with lung cancer, infections of the lower respiratory tract are often complicated, while It is not known whether ciliary function will be maintained in lung cancer lesion bronchus.

      We reported the newly developed simple method to evaluate patients bronchial mucoculliary movement using bronchoscopic sample. To evaluate human bronchial ciliary movement in the patients with lung cancer, the ciliary beat frequency (CBF) and amplitude (CBA) and drug reaction of bronchodilator were examined by our method using bronchoscope sample which collected in the transbronchial biopsy for the diagnosis.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Objective: Fifty eight patients with lung cancer were enrolled who had met the following eligibility criteria. 1) necessity of bronchoscopic biopy by the medical reason, 2) Adult and written informed consent, 3) tolerable organ function to perfume bronchoscopy.

      Method: When the bronchoscopy was performed in the patients with respiratory disease, bronchial lavage to the transbronchial biopsy site was examined to collect peripheral bronchial epithelial cells.

      After ciliary motion were observed to identify with microscopy, the cilliary beat were captured at 240 frames per second using a high-speed photographing function of the general-purpose digital video camera on the market. After inhalation of clinical dose of bronchodilator (tiotropium + Olodaterol or Fluticasone / Formoterol) the cilliary beat were captured again. By software analysis, frequency and amplitude of the ciliary movement was measured.

      4c3880bb027f159e801041b1021e88e8 Result

      There were cases in which epithelial cells could not be collected, 50 of 58 cases were able to analyze ciliary function. Ciliary epithelium in the patients with lung cancer was confirmed in the amplitude of 4 ~ 8μm and frequency of 5 ~ 20bps.

      It was observed that ciliary movement is significantly. activated by inhale bronchodilater, from 6.6 to 8.4 beat per second as frequency, and from 6.0 to 6.5 micrometer as amplitude.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Even in lung cancer lesion bronchus of the patients, ciliary function was maintained and it was shown that ciliary function will be activated by drug stimulation.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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