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  P3.01 - Advanced NSCLC (Not CME Accredited Session) (ID 967)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27465

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    P3.01-105 - Retrospective Analysis of Efficacy and Safety in Chinese Elderly Patients Treated with Nab-Paclitaxel (ID 12682)

    12:00 - 13:30  |  Author(s): Qiu Ping
    • Abstract
    • Slides

    Background
    

    Albumin-bound paclitaxel (nab-PC) could benefit advanced non-small cell lung cancer (NSCLC) either in first line or second line. However, the safety and efficacy in Chinese elderly population remains unclear. In this study, we retrospectively analyzed the efficacy and safety of nab-pc in Chinese elderly patients (≥65 year old) from a single cancer center.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    We retrospectively collected data from 75 patients who were treated with weekly nab-paclitaxel (125 or 130 mg/m²d1, d8) from Janurary 2010 to December 31, 2017 in Peking University Cancer Hospital. Among which, 33 patients were non-squamous NSCLC, and 42 patients were squamous NSCLC. Twelve of these patients received nab-paclitaxelas first line treatment (7 of which were combined with carboplatin) and 63 patients received single nab-paclitaxel as latter line treatment.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Results: Sixty-eight out of 75 patients were available for efficacy evaluation, the overall objective response rate (ORR) was 13.1 (10/68), disease control rate (DCR) was 69.3%(52/68), median progression free survival (PFS) was 5.2 months and overall survival was 12.2 months in the entire population. For fist-line and latter line setting subgroup, the ORR, DCR, PFS and OS were 18.2% and 14.0%; 90.9% and 73.7%; 6.7 months and 5.0 months; 17.7 months and 12.2 months, respectively. For the patients ≥70 years old, the PFS significantly longer compared with patient ＜70 years old (6.3 months vs. 3.7 months p=0.021; the same trend was observed in OS, however the difference was not significant (13.3 months vs. 10.0 months, p=0.089). For all grade of adverse events (AEs), the most common AEs were leukopenia (37.3%, n=28), anemia (40%, n=30) fatigue (18.7%, n=14) and Peripheral neuritis (17.3%, n=13) which were all manageable, and the incidence of grade 3 were 13.3% (10/75), no grade 4 AEs were found and no AEs related death. Totally 7 patients discontinued treatment because of AEs. And the incidence of AEs was not different among subgroups of patients defined with age (65≤age＜70, 70≤age<75 and age≥75).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    The efficacy of nab-paclitaxel in Chinese elderly patients was desirable. The toxicity was tolerable and manageable. Patients over 70 may benefit more from nab-paclitaxel. Prospective clinical trials are expected to further confirm the results.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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