Author of

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  P3.01 - Advanced NSCLC (Not CME Accredited Session) (ID 967)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27433

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    P3.01-77 - Clinical Characteristics of Korean Lung Cancer Patients with Programmed Death-Ligand 1 Expression (ID 12770)

    12:00 - 13:30  |  Author(s): Ha-Young Park
    • Abstract
    • Slides

    Background
    

    Programmed death-ligand 1 (PD-L1) is a transmembrane protein that binds to the programmed death-1 (PD-1) receptor and anti-PD-1 therapy enables the immune response against tumors. The aim of this study was to assess the clinical and pathologic characteristics of PD-L1 positive lung cancer patients in Korea. And we examined correlation between immunohistochemical assays.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    We retrospectively reviewed the clinical and pathologic data of pathologically proven lung cancer patients, and collected 267 cases of formalin-fixed, paraffin-embedded tissue sample from single institution. PD-L1 expression was detected by qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3. PD-L1 protein expression is determined by using Tumor Proportion Score (TPS), which is the percentage of viable tumor cells showing partial or complete membrane staining. We categorized according to the percentage of TPS; more than 1% or more than 50%. Among 267 patients, 34 were analyzed by both 22C3 and SP263 assays. We examined the concordance correlation between IHC assays.

    4c3880bb027f159e801041b1021e88e8 Result
    

    A total of 267 patients were enrolled and major histologic types were adenocarcinoma (69.3%). The majority was smoker (67.4%) and clinical stage IV (60.7%). Thirty one (11.6%) cases of EGFR mutation and 17 (6.4%) cases of ALK FISH positive were included. The patients who showed TPS ≥ 1% and 50% were 116 (42%) and 58 (21%), respectively. More than 1% of TPS group was consisted of adenocarcinoma (67.8%), squamous cell carcinoma (29.6%), and small cell carcinoma (1.9%) histology. And more than 50% of TPS group was composed of adenocarcinoma (72.4%), squamous cell carcinoma (22.4%). More than 1% of TPS group was significantly older than less than 1% of TPS group (64.83 ± 9.38 vs. 61.73 ± 10.78 years, p=0.014). The rate of poorly differentiated pathology was significantly higher in TPS ≥ 1% group (40.8% vs. 25.8%) and TPS ≥ 50% group (53.2% vs. 27.2%). There was no difference in smoking, EGFR mutation, ALK rearrangement status or biopsy site. Among 34 patients analyzed by both 22C3 and SP 263, 27 patients showed positive by both 22C3 and SP263, at the cut-off of 1% or higher. The concordance correlation coefficient was 0.826 (95% confidence interval: 0.736-0.916).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    In Korean lung cancer patients, PD-L1 positive group defined as TPS ≥ 1% was older than negative group. And major histology was poorly differentiated non-small cell lung cancer in both TPS ≥ 1% and 50% groups. And our results showed a high correlation between PD-L1 IHC expression data analyzed by 22C3 and SP263 assays.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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