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Jingyun Chen



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    P3.01 - Advanced NSCLC (Not CME Accredited Session) (ID 967)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.01-67 - Integrated Network Analysis to Understand the Potential Mechanisms of Hydroxychlrorquine in Non-Small Cell Lung Cancer Treatment (ID 13938)

      12:00 - 13:30  |  Presenting Author(s): Jingyun Chen

      • Abstract
      • Slides

      Background

      The aim of this study is to investigate the novel mechanisms of hydroxychloroquine in non-small cell lung cancer.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The primary targets and their related genes of hydroxychloroquine were compiled from open portals (DrugBank and STRING). Functional enrichments and pathway network were mined in DAVID and GlueGO databases. The cBioportal, Oncomine and Kaplan Meier Plotter were used to analyze the genetic alterations, mRNA expression as well as prognosis of target genes enriched in non-small cell lung cancer pathway.

      4c3880bb027f159e801041b1021e88e8 Result

      The biological effects of hydroxychloroquine depended on 3 primary targets (DNA, TLR7 and TLR9), and there was no common gene in all 3 primary directed protein targets. Functional enrichments indicated that hydroxychloroquine exerted beneficial effects on anticancer and anti-infectious disease, especially on non-small cell lung cancer. Pathway network and genetic alternatives of 5 enriched genes (CDKN2A, EGFR, KRAS, AKT1 and TP53)implied TP53 was the axis of pathway interactions in non-small cell lung cancer . Statistically significant prognoses of the 5 genes were also exhibited in lung adenocarcinoma, but not in squamous cell lung carcinoma.

      8eea62084ca7e541d918e823422bd82e Conclusion

      This study indicates that hydroxychloroquine may exert anti-tumor effect in non-small cell lung cancer via TP53 signaling axis.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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