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Mariko Fukui



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    P2.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 966)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.17-29 - Is Collagen Vascular Disease-Associated Interstitial Lung Disease a High Risk for Lung Cancer Surgery? (ID 12866)

      16:45 - 18:00  |  Author(s): Mariko Fukui

      • Abstract
      • Slides

      Background

      Interstitial lung disease (ILD) frequently coexists with collagen vascular disease (CVD), and most of such patients are treated with immunosuppressive agents. Although the prognosis of CVD-ILD is better than that of idiopathic interstitial pneumonias (IIPs), the effect of CVD-ILD on the outcome and postoperative complication, including acute exacerbation (AE), after lung cancer surgery are unknown.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      The subjects of this retrospective study were 2272 patients who underwent surgical resection of lung cancer at our institute between 2009 and 2016. We compared the characteristics, postoperative complication, and outcome of 18 patients with CVD-ILD with those of 201 Patients with IIPs. The pattern of ILD were based on chest computed tomography and classified into usual interstitial pneumonia (UIP) and the others.

      4c3880bb027f159e801041b1021e88e8 Result

      The numbers of UIP patterns were 7 (39%) in CVD-ILD and 77 (38%) in IIPs. Thirteen patients (72%) were taking corticosteroids and 6 patients (33%) were taking immunosuppressive agents in CVD-ILD. Although postoperative AE occurred in 6 (3%) in IIPs, there were no AE events in CVD-ILD. Female (P < 0.01), lower pack-year smoke (P = 0.04), never smoker (P = 0.04), high value of LDH (P < 0.01), and medication of corticosteroids or immunosuppressive agents (P < 0.01) were significantly more common in CVD-ILD. Although there were no significant differences on the incidents of postoperative complications and mortalities, the duration to postoperative onset of IP exacerbation in CVD-ILD were tended to be longer than IIPs (P = 0.07). There were no significant differences on the cause of death between the 2 groups..

      8eea62084ca7e541d918e823422bd82e Conclusion

      There were no significant differences on the outcome and the incidents of postoperative complication, including AE.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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    P3.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 982)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.16-25 - Impact of Diabetes Mellitus on Survival Outcome in Patients with Pathological Stage IA Non-Small Cell Lung Cancer (ID 12245)

      12:00 - 13:30  |  Author(s): Mariko Fukui

      • Abstract
      • Slides

      Background

      The aim of this study was to investigate the impact of diabetes mellitus (DM) on prognosis of non-small cell lung cancer (NSCLC) patients with pathological stage IA.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      A retrospective study was performed on 506 patients with pathological stage IA in NSCLC, who underwent complete resection between 2008 and 2012. We investigated the clinicopathological features and prognosis of patients with DM (DM group; N = 62) and those without (non-DM group; N = 444) retrospectively. Median follow-up period was 5.2 years.

      4c3880bb027f159e801041b1021e88e8 Result

      The DM group consisted of more males, high serum CEA level, history of smoking and heart disease, vascular invasion and lymphatic permeation than the non-DM group. 5-year overall survival (OS), recurrence free survival (RFS) and disease specific survival (DSS) rate in the DM group (5-year OS rate, 80.6%; 5-year RFS rate, 77.4%; 5-year DSS rate, 91.6%) were significantly worse than those in the non-DM group (5-year OS rate, 92.0%; 5-year RFS rate, 90.6%; 5-year DSS rate 97.6%) (p = 0.001, p = 0.001 and p = 0.014; respectively). The univariate and multivariate analyses revealed that DM was an independent prognostic factor for RFS and OS (P = 0.027 and P = 0.020, respectively). Relapse in the DM group was higher than that in the non-DM group (p = 0.036). Distant metastases in the DM group (10%) were significantly more common than in the non-DM group (3%) (p = 0.015).

      8eea62084ca7e541d918e823422bd82e Conclusion

      Pathological stage IA in NSCLC patients having diabetes mellitus have a decreased survival compared with those without.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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