Author of

• 25954

  +

  P2.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 966)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27335

    +

    P2.17-24 - Does the Change in Body Mass Index During Induction Chemo/Chemoradiotherapy Affect the Outcome of Surgery in Locally Advanced NSCLC? (ID 14199)

    16:45 - 18:00  |  Author(s): Ender Kurt
    • Abstract

    Background
    

    In the literature, the affect on prognosis due to changes in Body Mass Index (BMI) for patients diagnosed with cancer have been extensively analyzed. However, there are no studies investigating changes in BMI during induction therapy and its affect on postoperative outcomes. In this study, we aimed to identify how changes in BMI during induction therapy affected morbidity, mortality and long-term survival rates in patients undergoing surgery for locally advanced NSCLC.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    One hundred and seventy one patients with locally advanced NSCLC and undergoing lung resection after induction therapy between 2011 and 2016 were prospectively recorded into the database and retrospectively evaluated. Induction treatment consisted of chemotherapy in 131 (76.6%) and chemoradiation in 40 (23.4%) patients. Body mass index was calculated at the initaition of induction therapy and before surgery. Pathological complete response to induction treatment, morbidity, 90-days mortality, long-term survival and prognostic factors were compared in the light of BMI.

    4c3880bb027f159e801041b1021e88e8 Result
    

    All but 15 patients were male with a mean age of 59.4 (range 26-76y) years. The median BMI before induction treatment was 25.1 (16-39) and 25.2 (17-38) before surgery. The BMI decreased in 26.3% and remained steady/or increased in 73.7% of the patients during induction treatment. The complete response rate was 27(15.8%) patients [4 (11.8%) in the decreased BMI group and 23 (16.8%) in the BMI steady/increased group, p=0.47]. Morbidity rate was 42.6% ( 43.8% in decreased BMI and 38% in the BMI steady/increased group, p=0.5). Mortality rate was 4% (5.8% in decreased BMI and 3.6% in BMI steady/increased group, p=0.7). Three years survival rate was 71% (55.6% in the decreased BMI group and 76% in BMI steady/increased group, p=0.029)

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    In this study we observed that nutrutional status of the patients undergoing induction therapy and surgery needs clear attention because morbidity, mortality and long term survival rates were negatively impacted in patients with a decline in their BMI during induction treatment.

    6f8b794f3246b0c1e1780bb4d4d5dc53