Author of

• 25954

  +

  P2.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 966)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27314

    +

    P2.17-04 - Imiquimod Attenuates Radiation-Induced Pulmonary Fibrosis (ID 11769)

    16:45 - 18:00  |  Author(s): Hidir Esme
    • Abstract
    • Slides

    Background
    

    Radiation-induced lung injury (RILI) is a major dose limiting factor during thoracic irradiation. Imiquimod (I) stimulates the innate and adaptive immune pathways and induces cytokine production.We aimed to evaluate the impact of I RILI.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    Sixty rats were divided into 6 groups: Group (G) 1 control, G2 radiotherapy (RT) only, G3 and G4 5 and 10 mg/kg I; G5 and G6 RT plus 5 and 10 mg/kg I groups respectively. A single dose of 15 Gy RT was given to lungs. I was applied intraperitoneally with daily doses, until animals were sacrificed 6 and 16 weeks after RT. Lung tissues were dissected for light and electron microscopy.

    4c3880bb027f159e801041b1021e88e8 Result
    

    The inflammation, fibrosis and transforming growth factor (TGF)-β scores of study groups were significantly different at 6th and 16th week of RT (p< 0.001 for all). At 6th week of RT, pair-wise comparisons revealed that inflammation, fibrosis and TGF- β scores of did not different in both RT and non-RT groups. By 16th week of RT inflammation, fibrosis and TGF- β scores were significantly different between G2 and G5 (p values were 0.033, 0.041, and <0.001 respectively), and G2 and G6 (p values were 0.043, 0.002, and <0.001 respectively). By 16th week, there were vacuoles in alveolar epithelial cells and inter/pericellular edema in all RT groups. The vacuoles were larger and the intercellular edema was more prominent in G2 than both G5 and G6; however there weren’t any difference between G5 and G6.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Although I did not improve pneumonitis phase, I attenuated radiation-induced lung fibrosis.

    6f8b794f3246b0c1e1780bb4d4d5dc53

    Only Active Members that have purchased this event or have registered via an access code will be able to view this content. To view this presentation, please login or select "Add to Cart" and proceed to checkout.