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P2.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 966)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Presentations: 1
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
P2.17-04 - Imiquimod Attenuates Radiation-Induced Pulmonary Fibrosis (ID 11769)
16:45 - 18:00 | Author(s): Goknil Calik
Radiation-induced lung injury (RILI) is a major dose limiting factor during thoracic irradiation. Imiquimod (I) stimulates the innate and adaptive immune pathways and induces cytokine production.We aimed to evaluate the impact of I RILI.a9ded1e5ce5d75814730bb4caaf49419 Method
Sixty rats were divided into 6 groups: Group (G) 1 control, G2 radiotherapy (RT) only, G3 and G4 5 and 10 mg/kg I; G5 and G6 RT plus 5 and 10 mg/kg I groups respectively. A single dose of 15 Gy RT was given to lungs. I was applied intraperitoneally with daily doses, until animals were sacrificed 6 and 16 weeks after RT. Lung tissues were dissected for light and electron microscopy.4c3880bb027f159e801041b1021e88e8 Result
The inflammation, fibrosis and transforming growth factor (TGF)-β scores of study groups were significantly different at 6th and 16th week of RT (p< 0.001 for all). At 6th week of RT, pair-wise comparisons revealed that inflammation, fibrosis and TGF- β scores of did not different in both RT and non-RT groups. By 16th week of RT inflammation, fibrosis and TGF- β scores were significantly different between G2 and G5 (p values were 0.033, 0.041, and <0.001 respectively), and G2 and G6 (p values were 0.043, 0.002, and <0.001 respectively). By 16th week, there were vacuoles in alveolar epithelial cells and inter/pericellular edema in all RT groups. The vacuoles were larger and the intercellular edema was more prominent in G2 than both G5 and G6; however there weren’t any difference between G5 and G6.
Although I did not improve pneumonitis phase, I attenuated radiation-induced lung fibrosis.6f8b794f3246b0c1e1780bb4d4d5dc53
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