Author of

• 25953

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  P2.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 965)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27305

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    P2.16-46 - Clinical Outcomes and Treatment Strategies of Sarcomatoid Carcinoma of the Lung (ID 11272)

    16:45 - 18:00  |  Presenting Author(s): Yan Wang
    • Abstract
    • Slides

    Background
    

    Sarcomatoid carcinoma of the lung is characterized by worse prognosis, and generally felt to be chemo-refractory compared with other non-small cell lung cancer. We conduct this retrospective study to investigate the clinical characteristics of patients with sarcomatoid carcinoma of the lung and determine the optimal treatment strategies.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    We reviewed the medical records of 8176 patients with resected lung cancer in a single high-volume institution between 2008 and 2015. All patients with pathologically diagnosed sarcomatoid carcinoma were evaluated. Clinicopathologic data were analyzed using Kaplan-Meier analysis and Cox regression analysis. Subgroups stratified by pathological stage were analysed to determine the optimal treatment modality. We also conducted subgroup analysis of overall survival among pulmonary sarcomatoid carcinoma and other NSCLC patients.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Kaplan-Meier and Cox regression analyses showed pathological stage（8^th edition）is the independent prognostic factor(P=0.001, HR=2.601, 95%CI(1.447-4.675)) for pulmonary sarcomatoid carcinoma. Overall survival favored other NSCLC over PSC across subgroups.

    

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Pathological stage（8^th edition）is independent prognostic factor for sarcomatoid carcinoma of the lung. Surgery followed by adjuvant chemotherapy should be considered for stage I pulmonary sarcomatoid carcinoma. Further prospective studies are needed to confirm these results.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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• 25955

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  P3.01 - Advanced NSCLC (Not CME Accredited Session) (ID 967)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall

  • 27467

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    P3.01-107 - Correlation Study of Bone Metastasis and Cholesterol Level in Patients with Lung Adenocarcinoma (ID 11157)

    12:00 - 13:30  |  Presenting Author(s): Yan Wang
    • Abstract
    • Slides

    Background
    

    To explore the correlation between bone metastasis and laboratory examination such as cholesterol level in patients with lung adenocarcinoma.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    Medical records were studied for patients who were admitted into this high-volume institution from Jan 1, 2017 to the present. 114 patients diagnosed and treated as esophageal squamous cell carcinoma with bone metastasis were retrospectively analyzed for the present study. Along with them were 114 patients without bone metastasis in the control group.

    4c3880bb027f159e801041b1021e88e8 Result
    

    There was no significant statistical difference between groups with respect to neutrophils count, lymphocyte count, monocyte count, bilirubin, calcium ion, phosphorus, or blood sugar. Univariable analysis found that total cholesterol levels (OR: 0.230; 95% CI: 0.064–0.822; P=0.024) and triglyceride levels (OR: 0.001; 95% CI: 0.000–0.201; P=0.012) , and Multivariate analysis indicated that triglyceride levels (OR: 0.001; 95% CI: 0.000–0.327; P=0.020) were independently associated with development of bone metastasis in patients with lung adenocarcinoma.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Triglyceride levels were independently associated with the development of bone metastasis in patients with lung adenocarcinoma.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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