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Berat Sozen
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P2.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 965)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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P2.16-43 - Diabetes is a Negative Prognostic Factor in Non-Small Cell Lung Cancer Patients Undergoing Resectional Surgery (ID 14409)
16:45 - 18:00 | Author(s): Berat Sozen
- Abstract
Background
During the last decades, lung cancer has been a major health problem as it is one of the leading causes of cancer death among both genders all over the world other than subsaharan Africa. Diabetes mellitus(DM) can also be a possible prognostic factor because it effects similar age groups with non small cell lung cancer(NSCLC).
A total of 634 patients with resected NSCLC seen between January 2004 and June 2017 were included in the study. The preoperative mediastinal staging was performed by video-assisted cervical mediastinoscopy or video-assisted mediastinoscopic lymphadenectomy in all patients except those with peripheral cT1N0 non-adenocarcinoma tumors. Possible prognostic factors such as presence of diabetes mellitus(DM), gender, age, smoking history, clinical stage, histology and laboratory parameters were recorded.
4c3880bb027f159e801041b1021e88e8 Result
A total of 84 patients (13.2%) were found to have DM. The median survival time of patients with or without DM were 33.0 months(95% confidence interval: 26.5-39.5 months) and 127.0 months respectively(p<0.001). T and N factors were found to be prognostic parameters (p<0.001, p=0.01 respectively). When we analyzed only male patients(n=544), DM was found to be highly significantly associated with worse survival (p<0.001). Multivariate Cox analysis showed that absence of DM(p<0.001), absence of nodal metastasis(p=0.007), and lower T factor (p=0.04) were independently good prognostic elements in resected patients.
8eea62084ca7e541d918e823422bd82e Conclusion
We concluded that, presence DM was independently associated with worse survival in lung cancer patients who underwent resectional surgery.
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