Author of

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  P2.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 965)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 2
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27301

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    P2.16-42 - Standard Mediastinoscopy Versus Video-Assisted Mediastinoscopic Lymphadectomy in Clinical N1 Non-Small Cell Lung Cancer (ID 14399)

    16:45 - 18:00  |  Author(s): Kamil Kaynak
    • Abstract
    • Slides

    Background
    

    A considerable number of patients with clinical N1 (cN1) non-small cell lung cancer (NSCLC) based on positron emission tomography–computed tomography (PET-CT) imaging have occult mediastinal nodal involvement (N2 disease). We aimed to compare the role of video-assisted mediastinoscopy lymphadenectomy(VAMLA) and standard mediastinoscopy in pre-resectional mediastinal staging in patients with cN1 disease.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 821 patients with potentially resectable NSCLC seen between January 2004 and November 2016 were included in the study. The preoperative mediastinal staging was accomplished by standard cervical mediastinoscopy or VAMLA in all patients except those with peripheral cT1N0 tumors. Resection via thoracotomy or video-assisted thoracoscopic surgery was performed in patients with no mediastinal lymph node metastasis. A systematic lymph node sampling or systematic lymph node dissection was performed during resectional surgery. Surgical-pathological results were compared with the pathological findings. Primary aim was to compare the sensitivities and accuracies to detect N2 by two methods.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Out of 85 patients with cN1 on PET-CT, a mediastinal metastasis was disclosed in 29 patients (34.1%). Of 56 patients who underwent VAMLA 24(42.9%) were found to have N2/3 disease, whereas standard mediastinoscopy revealed N2/N3 disease in 7 patients(24.1%)(p=0.029) VAMLA and standard mediastinoscopy had both sensitivities of 85.7% to detect N2 disease(p=1). The NPVs were 87.5% and 85.7% by VAMLA and standard mediastinoscopy respectively(p=0.821).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    VAMLA is more accurate to detect mediastinal nodal disease in operable cN1 lung cancer, and could be used in patients with cN1 NSCLC patients since it discloses N2 disease in an important fraction of patients.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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    P2.16-43 - Diabetes is a Negative Prognostic Factor in Non-Small Cell Lung Cancer Patients Undergoing Resectional Surgery (ID 14409)

    16:45 - 18:00  |  Author(s): Kamil Kaynak
    • Abstract
    • Slides

    Background
    

    During the last decades, lung cancer has been a major health problem as it is one of the leading causes of cancer death among both genders all over the world other than subsaharan Africa. Diabetes mellitus(DM) can also be a possible prognostic factor because it effects similar age groups with non small cell lung cancer(NSCLC).

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 634 patients with resected NSCLC seen between January 2004 and June 2017 were included in the study. The preoperative mediastinal staging was performed by video-assisted cervical mediastinoscopy or video-assisted mediastinoscopic lymphadenectomy in all patients except those with peripheral cT1N0 non-adenocarcinoma tumors. Possible prognostic factors such as presence of diabetes mellitus(DM), gender, age, smoking history, clinical stage, histology and laboratory parameters were recorded.

    4c3880bb027f159e801041b1021e88e8 Result
    

    A total of 84 patients (13.2%) were found to have DM. The median survival time of patients with or without DM were 33.0 months(95% confidence interval: 26.5-39.5 months) and 127.0 months respectively(p<0.001). T and N factors were found to be prognostic parameters (p<0.001, p=0.01 respectively). When we analyzed only male patients(n=544), DM was found to be highly significantly associated with worse survival (p<0.001). Multivariate Cox analysis showed that absence of DM(p<0.001), absence of nodal metastasis(p=0.007), and lower T factor (p=0.04) were independently good prognostic elements in resected patients.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    We concluded that, presence DM was independently associated with worse survival in lung cancer patients who underwent resectional surgery.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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