Author of

• 25953

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  P2.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 965)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27299

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    P2.16-40 - Impact of Preoperative Pectoralis Muscle Quantity and Density on Outcome After Complete Resection of Non-Small Cell Lung Cancer (ID 12135)

    16:45 - 18:00  |  Presenting Author(s): Changbo Sun
    • Abstract
    • Slides

    Background
    

    Body composition measures may predict outcomes of cancer surgery. In this study we evaluated the prognostic significance of pectoralis muscle quantity and density in patients with surgical non-small cell lung cancer.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    Preoperative pectoralis muscle quantity and density were retrospectively assessed in 181 patients undergoing lobectomy and lymph node dissection for non-small cell lung cancer from 2009 to 2013. The pectoralis muscle index (cross-sectional area/height²) and density (average Hounsfield unit, HU) at the fourth thoracic vertebra level were measured and calculated on preoperative plain computed tomography. Overall survival was analyzed between the lowest gender-specific quartile of the pectoralis muscle index and density and the other quartiles.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Positive correlations between pectoralis muscle index and density and body mass index (BMI) were identified in the cohort (Pearson's r=0.349, p＜0.001; r=0.206, p=0.005, respectively). The gender-specific lowest quartile cut-off values of the pectoralis muscle index and density was 10.14cm²/m² and 28.97HU for males, 7.86cm²/m² and 21.23HU for females, respectively. The cumulative five-year overall survival rates were significantly shorter in patients with low pectoralis muscle index (51.7% vs. 76.0%, p=0.009), while for low pectoralis density (66.0% vs. 70.7%, p=0.391). The multivariate analysis including age, smoke index, BMI, c-reactive protein, carcinoembryonic antigen and pathologic stage revealed that the pectoralis muscle index, not the pectoralis density or BMI, was an adverse independent risk factor for overall survival (p=0.002, hazard ratio: 2.815, 95% confidence interval: 1.473–5.377).

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    A low preoperative pectoralis muscle index was associated with a poor postoperative outcome in surgical patients with non-small cell lung cancer. Pectoralis muscle quantity which is more predictive than density and BMI as a convenient measure, may be included in the preoperative assessment when surgical intervention is considered for non-small cell lung cancer.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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