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Takuro Tasaki



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    P2.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 965)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.16-11 - Prognostic Role of Combined Pulmonary Fibrosis and Emphysema (CPFE) in Patients with Clinical Stage I Lung Cancer. (ID 11264)

      16:45 - 18:00  |  Author(s): Takuro Tasaki

      • Abstract

      Background

      The prognostic role of CPFE in lung cancer is not fully understood. The purpose of this study is to evaluate the prognostic role of combined pulmonary fibrosis and emphysema (CPFE) in patients with clinical stage I primary lung cancer with interstitial pneumonia (IP).

      a9ded1e5ce5d75814730bb4caaf49419 Method

      CPFE was defined as the presence of both emphysema and IP on high-resolution computed tomography (HRCT). Of 836 consecutive patients with clinical stage I primary lung cancer who underwent complete resection between April 2007 and March 2016, 65 patients with CPFE were identified. The log-rank tests and Cox proportional hazard models were used to test for survival differences.

      4c3880bb027f159e801041b1021e88e8 Result

      There was a significant difference in overall survival (OS) between patients with CPFE (n = 65: 5 y-OS rates, 62.6%) and those without CPFE (n = 771: 5 y-OS rates, 86.5%, P <0.001). However, in patients with interstitial pneumonia on HRCT (n = 115), there was no significant difference in OS between patients with CPFE (n = 65: 5 y-OS rates, 62.5%) and those without CPFE (n = 50: 5 y-OS rates, 59.4%, P = 0.84). In patients with interstitial pneumonia, multivariable backward stepwise Cox analysis revealed that histology, %DLCO, radiologic IP pattern, and surgical procedure were independent prognostic factors for OS, but the presence of CPFE was not.

      8eea62084ca7e541d918e823422bd82e Conclusion

      CPFE was not an independent prognostic factor for OS in patients with clinical stage I lung cancer with IP. The presence of interstitial pneumonia pattern may explain poor survival in patients with CPFE.

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