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Wen-zhao Zhong



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    P2.12 - Small Cell Lung Cancer/NET (Not CME Accredited Session) (ID 961)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.12-11 - A Prognostic Model Integrating Immunohistochemistry Markers for Extensive-Disease Small-Cell Lung Cancer (ID 11828)

      16:45 - 18:00  |  Author(s): Wen-zhao Zhong

      • Abstract
      • Slides

      Background

      Extensive-disease small-cell lung cancer (ED-SCLC) is a subtype of high-grade neuroendocrine carcinoma (HGNEC) with poor prognosis. We tend to build a prognostic nomogram and illustrate the failure pattern of first line etoposide/Irinotecan with paclitaxel (EP/IP) treatment.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      250 ED-SCLC patients received first line EP/IP treatment were enrolled. Cox regression analysis was used to identify the prognostic factors to establish nomogram. The predictive accuracy of nomogram was evaluated by concordance index (C-index). Further stratification based on Ki67 and brain metastasis was performed through X-tile plot and Kaplan Meier.

      4c3880bb027f159e801041b1021e88e8 Result

      Cox regression analysis indicated brain metastasis as the prognostic factor and we further selected NSE, gender, TTF-1, Syn, tumor size and smoking status under clinical consideration for nomogram. C-index of nomogram suggested 0.65 with moderate predictive effect. Subgroup analysis showed patients with Ki67 lower than 85% had poorer prognosis than those over 90% (HR 0.59, 95%CI 0.39-0.92, p=0.02). Those without brain metastasis at baseline achieving partial response (PR)/complete response (CR) suggested no prognostic significance in brain progression compared to other progression group.

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      8eea62084ca7e541d918e823422bd82e Conclusion

      Established nomogram could well predict prognosis in ED-SCLC. Ki67 might play a potential role in prognosis of SCLC. Application of preventive cranial irradiation might be challenged in ED-SCLC patients without brain metastasis.

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