Author of

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  P2.12 - Small Cell Lung Cancer/NET (Not CME Accredited Session) (ID 961)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 27162

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    P2.12-09 - Efficacy and Safety of Carboplatin and Paclitaxel for Patients Preexisting Interstitial Lung Disease with Small Cell Lung Cancer (ID 14309)

    16:45 - 18:00  |  Author(s): Masafumi Sata
    • Abstract
    • Slides

    Background
    

    The small cell lung cancer (SCLC) is chemosensitive. However, in patients with interstitial lung disease (ILD) , chemotherapy-related acute exacerbation (AE) of ILD is one of the most lethal complications. Results of some reports suggest that patients with ILD and SCLC might benefit from chemotherapy, but the efficacy and safety are unclear.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    Retrospective study of patients preexisting ILD with SCLC who treated with carboplatin and paclitxel after second-line chemotherapy. Between January 2012 and July 2017, 17patients preexisting ILD with SCLCwho treated carboplatin and paclitaxel.

    4c3880bb027f159e801041b1021e88e8 Result
    

    Among 17 patients the overall response rate (ORR) was 35%. The median progression free survival (PFS) was 3.5 months(95% C.I. 1.9-4.0 months), whereas he median survival time was 11.8 months(95%C.I. 8.6-15.5 months). The most common grade 3-4 toxicity was neutropenia (71 %), one patient (6%) suffered from febrile neutropenia. Two patients (12%) experienced chemotherapy-related exacerbation of ILD. There were no treatment-related deaths.

    

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Carboplatin and Paclitxel for patients preexisting Interstitial Lung Disease with small cell lung cancer are tolerable and can be a treatment option.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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