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Abdellatif Benider



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    P2.11 - Screening and Early Detection (Not CME Accredited Session) (ID 960)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.11-11 - Identification of the Genetic Determinants of Susceptibility to Lung Cancer in a Moroccan Cohort (ID 12508)

      16:45 - 18:00  |  Author(s): Abdellatif Benider

      • Abstract
      • Slides

      Background

      Lung cancer is the most common cause of death from cancer worldwide, estimated to be responsible 1.59 million deaths, representing 19.4% of all cancer types. Representing 80–85% of all cases non-small cell lung cancer (NSCLC) is the most predominant type of lung cancer. Lung cancer has been recognized as a complex multifactorial disease resulting from the interactions between various genetic and environmental factors. Identification of genes involved in the occurrence and development of lung cancer could contribute to further understanding of the underlying mechanisms, and even a very important additional appropriate prevention strategies and targeted treatments for reducing lung cancer burden. Many studies have suggested that key cytokines in inflammation pathways may exert important roles in the etiology of lung cancer. The aim of this study was to investigate whether common variants in inflammatory and immune response genes influence lung cancer risk in Moroccan patients.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Using a candidate gene approach, 9 single nucleotide polymorphisms (SNPs) in 5 genes were assessed in 308 controls and 120 lung cancer patients. Genotyping was performed with the TaqMan® allelic discrimination technology. The results were analysed using SPSS 24.0 software.

      4c3880bb027f159e801041b1021e88e8 Result

      Among the 5 studied genes, we found a significant association for the IL17A ( rs7747909) polymorphisms, IL-6_rs2069840a trend of association was observed for without reaching the significance level. No significant association was observed for the remaining SNPs in the following genes: MIF_rs755622, IL-6R_rs2228145, IL6ST_rs2228044, TYK2_(rs2304856, rs34536443, rs35018800), STAT3 rs2293152.

      8eea62084ca7e541d918e823422bd82e Conclusion

      The results founded suggest the important role of genetically determined high inflammatory response in the pathogenesis of lung cancer in the Moroccan population.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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