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Zoltán Szállási
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P2.04 - Immunooncology (Not CME Accredited Session) (ID 953)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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P2.04-08 - Platinum-Based Chemotherapy is Associated with Altered PD-L1 Expression in Lung Cancer (ID 13755)
16:45 - 18:00 | Author(s): Zoltán Szállási
- Abstract
Background
While the predictive value of programmed cell death ligand-1 (PD-L1) protein expression for immune checkpoint inhibitor therapy of lung cancer has been extensively studied, the impact of standard platinum-based chemotherapy on PD-L1 or programmed cell death-1 (PD-1) expression is unknown. The aim of this study was to determine the changes in PD-L1 expression of tumor cells (TC) and immune cells (IC), in PD-1 expression of IC, and in the amount of stromal mononuclear cell infiltration after platinum-based chemotherapy in patients with lung cancer.
a9ded1e5ce5d75814730bb4caaf49419 Method
We determined the amount of stromal mononuclear cells and PD-L1/PD-1 expressions by immunohistochemistry in bronchoscopic biopsy samples including 20 adenocarcinomas (ADC), 15 squamous cell carcinomas (SCC), 2 other types of non-small cell lung cancer (NSCLC), and 4 small cell lung cancers (SCLC) together with their corresponding surgical resection tissues after platinum-based chemotherapy.
4c3880bb027f159e801041b1021e88e8 Result
PD-L1 expression of TC decreased in 10 patients (24.4%) and increased in 3 patients (7.32%) after neoadjuvant chemotherapy (p=0.051). The decrease in PD-L1 expression, however, was significant only in patients who received cisplatin-gemcitabine combination (p=0.020), while in the carboplatin-paclitaxel group no similar tendency could be observed (p=0.432). There was no difference between ADC and SCC groups. Neither PD-1 expression nor the amount of stromal IC infiltration showed significant changes after chemotherapy.
8eea62084ca7e541d918e823422bd82e Conclusion
This is the first study, in which both PD-L1 and PD-1 expression were analyzed together with the amount of stromal IC infiltration in different histological subtypes of lung cancer before and after platinum-based chemotherapy. Our results confirm that chemotherapy decreases PD-L1 expression of TC in a subset of patients, therefore rebiopsy and re-evaluation of PD-L1 expression may be necessary for the indication of immune checkpoint inhibitor therapy.
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