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Lingjuan Chen



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    P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.01-127 - Efficacy of Endostar Combined with Whole Brain Radiotherapy in Patients with NSCLC Brain Metastases (ID 14231)

      16:45 - 18:00  |  Author(s): Lingjuan Chen

      • Abstract
      • Slides

      Background

      Brain metastasis (BM) is the leading cause of poor prognosis, recurrence, and death in non-small-cell lung cancer (NSCLC) patients. The effectiveness of whole-brain radiotherapy is unsatisfactory. Endostar was reported as an anti-angiogenic agent, which could promote vascular normalization in tumor. This study is to investigate the influence of endostar combined with cranial radiation to cerebral blood flow, immune status and survival of the patients.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      28 NSCLC patients with multiple brain metastasis(more than four)were randomly divided into two groups. The experimental group (n = 14) received WBRT (30Gy/10F) combined with Endostar (15mg/m2, 7days), and the control group (n=14) received WBRT (30Gy/10F) alone. Magnetic resonance perfusion imaging was carried out pre- and one month post-radiation to detect regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF) and mean transit time (MTT) of the contrast medium. The changes of blood T lymphocyte subpopulation, the cognitive function and overall healthy level were evaluated pre- and post- radiation every two months against the MMSE, MoCA and EORTC QLQ-C30 scales. Moreover, Tumor progression was established by certified oncologists based on whole brain MRI scan.

      4c3880bb027f159e801041b1021e88e8 Result

      In the endostar group, rCBV, rCBF and MTT had a 122%, 210% and 11% higher in the target lesion region one month post radiation, compared with baseline data, while in the control group, rCBV, rCBF and MTT had a 18%, 20% and 26% lower change. These results showed a significant improvement of the cerebral perfusion in the endostar group. The T lymphocyte subpopulation increased in the Endostar group, especially the CD8+ T lymphocyte with a significant difference compared with the control group(p=0.0233). At the same time, the intracranial PFS (iPFS) was 349 days vs. 287 days and the PFS was 229 days vs. undefined between the Endostar group vs. the control group, but neither with significant difference, may for the limit of sample size. After cranial radiation, the cognitive function, physical, role, social and emotional functions improved in the endostar group, while a small fluctuation in the control group.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Our study showed that endostar could promote vessel normalization and improve cerebral perfusion, and ameliorate the immune status, cognitive function and quality of life of the patients, which may also improve the survival of the patients.

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