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Lili Jiang



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    P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.01-114 - The Correlation Among PD-L1 Expression, TMB and Lung Immune Prognostic Index in Chinese Patients with Advanced Lung Adenocarcinoma (ID 13896)

      16:45 - 18:00  |  Author(s): Lili Jiang

      • Abstract
      • Slides

      Background

      Anti-PD-1/PD-L1 immunotherapy was approved as first-line treatment on the part of NSCLC patients, but not all can benefit, some studies have shown that PD-L1 expression, Tumor Mutation Burden (TMB) and Lung Immune Prognostic Index (LIPI) can be respectively used as an effect predictor of NSCLC immunotherapy. We aim to explore the correlation of the three predictors in Chinese patients with advanced lung adenocarcinoma.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We enrolled 53 biopsy specimens of the advanced lung adenocarcinoma patients from four China centers, measured complete blood cell counts and lactate dehydrogenase (LDH) before biopsy, detected PD-L1 level by three IHC assays (22C3, 28-8, SP263) ,driver genes and TMB by NGS. LIPI was divided into three groups.

      4c3880bb027f159e801041b1021e88e8 Result

      In the cohort, 28 (52.8%) were male; median age was 59 (range, 34-81) years. There were 7 (13.2%, 7/53) with positive PD-L1(≥50%) based on 22C3. Three assays were highly concordant for tumor cells (ρ=0.740-0.826), lower for immune cells (ρ=0.462-0.543). Six (of 34,17.6%) were high TMB (at least 10/Mb). All were male (p=0.031), in which 5 were associated with TP53 mutation, 3 had DNA replication or damage repair–related gene mutations and 4 showed high PD-L1 on immune cells (p=0.031). LIPI didn't show significant correlation with PD-L1 or TMB (p>0.05). 3 of 20 with targetable driver gene alterations (ALK/EGFR/ROS1) were high PD-L1 or TMB. In the targetable driver gene wild cases, there were 8 (of 14) high PD-L1 or TMB.figure.png

      8eea62084ca7e541d918e823422bd82e Conclusion

      28-8, 22C3 and SP263 assays were aligned on tumor cell staining.There was no significant correlation among PD-L1, TMB and LIPI, which may be independent and complemented. High TMB might occur in male, show high PD-L1 on immune cells and accompanied with TP53 mutations. High PD-L1 or TMB was frequently found in the targetable driver gene wild cases.The prognostic value of PD-L1 and TMB on advanced NSCLC will be further followed.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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