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Peng Shen
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P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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P2.01-85 - The Efficacy of the Traditional Chinese Medicine as Maintenance Therapy for Advanced Non-Small Cell Lung Cancer: A Meta-Analysis (ID 12109)
16:45 - 18:00 | Presenting Author(s): Peng Shen
- Abstract
Background
Maintenance therapy is very important for patients with advanced non-small cell lung cancer (NSCLC). To evaluate traditional Chinese medicine (TCM) as maintenance therapy for advanced NSCLC patients, we performed a meta-analysis of prospective randomized controlled trials (RCTs).
a9ded1e5ce5d75814730bb4caaf49419 Method
12 databases were searched up to April 2016. All RCTs comparing TCM and control treatment as maintenance therapy for stage III to IV NSCLC patients in non-progression status after completing first-line chemotherapy were retrieved. Total 25 RCTs with 1654 patients were enrolled from March 2005 to June 2014.
4c3880bb027f159e801041b1021e88e8 Result
We found that TCM as maintenance therapy significantly increased the overall response rate (ORR) (risk ratio (RR)=2.23 95% confidence interval (CI)=1.28-3.88 P=0.004) and the disease control rate (DCR) (RR=3.15 95% CI=2.12-4.69 P<0.00001, Fig 1), while no significant difference was observed in the overall survival (OS) (P=0.44). Significant improvement was found in progression free survival (PFS)(HR=1.67 95% CI=0.40-2.93 P=0.01) and karnofsky performance status (KPS) in the TCM group (RR=3.26 95% CI=2.42-4.38 P<0.00001, Fig 2). There was no complication reported in these studies.
8eea62084ca7e541d918e823422bd82e Conclusion
TCM appears to be efficacious and well tolerated to be used as maintenance therapy for advanced NSCLC patients in non-progression status after completing the first-line chemotherapy. TCM as maintenance therapy is worth further study in future investigations.
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