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  P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 26887

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    P2.01-83 - Evaluation of Dynamic Thiol/Disulphide Homeostasis in Advance Non-Small Cell Lung Cancer and Small Cell Lung Cancer (ID 13804)

    16:45 - 18:00  |  Author(s): Muhammed Bulent Akinci
    • Abstract
    • Slides

    Background
    

    The complicated pathogenesis of lung cancer is the mainstay of all its different histological subtypes. Oxidative stress has detrimental effects on chronical diseases as well as cancer. Thiol groups which have high antioxidant capacity, turn to disulpide (DS) groups with biochemical reactions that neutralize different oxidant compounds. Thiol/Disulpide homeostasis (TDH) has significant effects on cell mechanisms, transcription and apoptosis. Here, we present the role of dynamic TDH in both advanced non-small cell (NSCLC) and small cell lung cancer (SCLC) patients.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    The patients who diagnosed with NSCLC and SCLC between 2015 and 2017 prospectively analysed. Serum samples of the patients obtained at the time of diagnosis and after first-line treatment. TDH tests were measured by the automated spectrophotometric method.

    4c3880bb027f159e801041b1021e88e8 Result
    

    57 patients (43 NSCLC and 14 SCLC) and 50 healthy controls enrolled to study. There was no statistical difference in age (median 61 and 60.5) and sex status between groups.Native thiol (NT) and total thiol (TT) levels were significantly lower in the patients’ group (Table 1).DS/NT ratio which is the best indicator of antioxidant capacity reached statistical significance between NSCLS patients and controls (p=0.04). After median 27.2 months follow-up,median overall survival (OS) was 9.5 months in NSCLC and 12.3 months in SCLC groups.Thiol or DS variables had no effect on survival.13 of the 30 patients had progressive disease after first-line chemotherapy. DS levels and DS/NT ratio were lower in patients after progression compared with levels at the time of diagnosis (p=0.013 and 0.033).

    Variable	Patients Median (min-max)	Controls Median (min-max)	p
    Native Thiol	358 (215-3261)	429 (313-607)	<0.001
    Disulpide	20.8 (0.05-55)	20 (8.4-37)	0.98
    Total Thiol	398 (253-573)	464 (354-632)	<0.001
    Disulpide/ Native Thiol	0.05 (0.01-0.19)	0.05 (0.02-0.14)	0.08

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Lower levels of thiol groups may contribute to lung cancer pathogenesis as a result of enhanced oxidative stress.The deficiency of this antioxidant compounds may relate to structural damage of signal, transcription, apoptosis mechanisms in lung cancer cell lines. The lower levels of DS and DS/NT ratio after progression may be an indicator of the high tumor volume and enhanced cell turnover.

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