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Hee Kyung Ahn



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    P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.01-55 - Dual-Energy CT Scan to Evaluate Sarcopenia in Lung Cancer in Comparison with Conventional CT Scan (ID 12691)

      16:45 - 18:00  |  Author(s): Hee Kyung Ahn

      • Abstract

      Background

      Depletion of skeletal muscle mass (sarcopenia) have been associated with poor prognosis in patients with malignancy. Although CT-determined skeletal muscle index (muscle area/height2, cm/m2) is regarded as a reference standard to evaluate the presence of sarcopenia, it is unclear the agreement of DECT derived images on the quantification of skeletal muscle area (SMA). The purpose of this study to evaluate the agreement of SMA quantification between dual-energy CT (DECT) derived images (virtual non-contrast; VNC and post-contrast weight-average 120kVp images) and conventional non-contrast CT image.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      For a total 128 lung cancer (LCA) patients who underwent DECT at the time of diagnosis, SMA were measured using non-contrast CT, and DECT images (post-processed VNC and weight-average 120kVp). Paired T-test was used to compare the quantification results, and intraclass correlation coefficients (ICC) for the agreement between three scan results.

      4c3880bb027f159e801041b1021e88e8 Result

      The agreement was excellent (ICC=0.991) between three images. However, SMA was significant higher in VNC (mean±SD, 125.2±23.8cm2, p<0.001) and weight-average 120kVP (110.4±22.0cm2, p<0.001) in comparison with non-contrast CT (107.4±22.7cm2). When using recently proposed L1 muscle index cutoff (46 cm/m2 for male, 29 cm/m2 for female) for sarcopenia, the prevalence of CT-determined sarcopenia is significantly decreased using weight-average 120kVp and VNC to 53.1% and 22.7%, compared with 58.6% using non-contrast CT.

      8eea62084ca7e541d918e823422bd82e Conclusion

      DECT derived VNC and weight-average 120kVp images slightly overestimate SMA. Same scan parameter is recommended to minimize measurement error to evaluate sarcopenia.

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    P3.11 - Screening and Early Detection (Not CME Accredited Session) (ID 977)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.11-12 - Comparison of Cancer Screening Adherence According to Smoking Status: Korea National Health and Nutrition Examination Survey 2010-2012 (ID 12687)

      12:00 - 13:30  |  Author(s): Hee Kyung Ahn

      • Abstract
      • Slides

      Background

      Smokers who are aged 55 to 74 years with 30 pack-years or more of smoking-history are regarded as high risk subjects for lung cancer, and recent study revealed lung cancer screening with low-dose CT (LDCT) could reduce lung cancer mortality of high-risk individuals. The purpose of this study was to compare the general medical checkups and cancer screening practice pattern according to self-reported smoking status.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Using a representative dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) IV from 2010 to 2012, we compared the adherence of general medical checkups and cancer (gastric, colorectal, breast, and cervical cancer) screening practice of Korean adults (55-74 years) according to self-reported smoking status; heavy smokers (≥ 30PY), non-heavy smokers (< 30PY), and never-smokers. Socio-demographic factors (gender, age group, obesity, education, marital status, income, insurance status), health-related lifestyle behavior (drinking status, exercise), and comorbidities (HTN, DM, hyperlipidemia, and self-reported health status) were also collected.

      4c3880bb027f159e801041b1021e88e8 Result

      For the 5,480 respondents, the weighted prevalence of heavy smokers, non-heavy smokers, and never-smokers was 19.3%, 23.5%, and 57.2%, respectively. The overall screening rate was 70.7% (health), 59.1% (stomach cancer), 58.1% (colorectal cancer), 59.1% (breast cancer), and 48.9% (cervical cancer). The screening rates for colorectal cancer are lower in heavy smokers compared with never-smokers even after adjusting covariates (OR=0.71, 95% CI=0.52-0.95). The adherence of general medical checkups and other cancer (gastric, breast, and cervical cancer) screening were not different according to self-reported smoking status.

      8eea62084ca7e541d918e823422bd82e Conclusion

      The results of this study suggest that high risk subjects for lung cancer were less likely to be screened for colorectal cancer than never-smokers, however, no difference was observed in the adherence of general medical checkups and other cancer screening. This finding provides a better understanding of the screening practice adherence for this population.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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