Author of

• 25938

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  P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall

  • 26854

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    P2.01-55 - Dual-Energy CT Scan to Evaluate Sarcopenia in Lung Cancer in Comparison with Conventional CT Scan (ID 12691)

    16:45 - 18:00  |  Author(s): Hee Young Lee
    • Abstract

    Background
    

    Depletion of skeletal muscle mass (sarcopenia) have been associated with poor prognosis in patients with malignancy. Although CT-determined skeletal muscle index (muscle area/height², cm/m²) is regarded as a reference standard to evaluate the presence of sarcopenia, it is unclear the agreement of DECT derived images on the quantification of skeletal muscle area (SMA). The purpose of this study to evaluate the agreement of SMA quantification between dual-energy CT (DECT) derived images (virtual non-contrast; VNC and post-contrast weight-average 120kVp images) and conventional non-contrast CT image.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    For a total 128 lung cancer (LCA) patients who underwent DECT at the time of diagnosis, SMA were measured using non-contrast CT, and DECT images (post-processed VNC and weight-average 120kVp). Paired T-test was used to compare the quantification results, and intraclass correlation coefficients (ICC) for the agreement between three scan results.

    4c3880bb027f159e801041b1021e88e8 Result
    

    The agreement was excellent (ICC=0.991) between three images. However, SMA was significant higher in VNC (mean±SD, 125.2±23.8cm², p<0.001) and weight-average 120kVP (110.4±22.0cm², p<0.001) in comparison with non-contrast CT (107.4±22.7cm²). When using recently proposed L1 muscle index cutoff (46 cm/m² for male, 29 cm/m² for female) for sarcopenia, the prevalence of CT-determined sarcopenia is significantly decreased using weight-average 120kVp and VNC to 53.1% and 22.7%, compared with 58.6% using non-contrast CT.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    DECT derived VNC and weight-average 120kVp images slightly overestimate SMA. Same scan parameter is recommended to minimize measurement error to evaluate sarcopenia.

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