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James Melotek



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    P2.01 - Advanced NSCLC (Not CME Accredited Session) (ID 950)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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      P2.01-07 - Safety and Efficacy of LATTICE Radiotherapy in Voluminous Non-Small Cell Lung Cancer: A Retrospective Study of 10 Patients Over 7 Year Period (ID 14098)

      16:45 - 18:00  |  Presenting Author(s): James Melotek

      • Abstract

      Background

      Lattice radiotherapy (LRT) is a novel technique of delivering heterogeneous doses of radiation for the management of voluminous tumors which are not amenable to surgical resection. Built from the conventional 2-dimensional GRID, LRT utilizes the power of new technology in the field of radiation therapy to implement 3-dimensional dosimetry plans. LRT allows delivery of higher doses of radiation to small spheres, also called vertices, in the interior of the bulky tumors limiting the exposure of surrounding healthy tissue to unacceptably high doses of radiation.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Ten patients with non-small cell lung cancer (NSCLC): Nine males and 1 female, with ages from 49 to 87 with a median of 70 who presented with bulky, unresectable primary tumors were treated with LRT during a 7-year period. Follow-up ranged from 4 to 73 months with a median of 10 months. All patients received one initial LRT fraction of 18 Gy in the lattice vertices and 3 Gy in the tumor periphery. All patients continued treatment with conventional radiation given in 25 to 33 daily fractions of 1.8 Gy to 2 Gy each. Image guided radiation therapy IGRT with CBCT and Volumetric Arc Therapy technique were used in all patients.

      4c3880bb027f159e801041b1021e88e8 Result

      There was no associated morbidity or mortality to the addition of LRT in these patients. There was a significant decrease in tumor volume from the time of planning CT to the last f treatment imaging.

      8eea62084ca7e541d918e823422bd82e Conclusion

      In this early experience, LRT appears to be a safe and effective modality of treatment for bulky NSCLC. LRT should be considered for non-surgical patients presenting with voluminous tumors. It is postulated that this technique induces changes in the tumor microenvironment leading to a more effective tumor control. More research is needed to elucidate the mechanisms by which LRT is effective in the reduction of tumor size.

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