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Wei Yang

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    P1.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 949)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.17-19 - Correlation of Dosimetric and Clinical Factors with Radiation Pneumonitis in Lung Cancer Patients Received Involved-Field IMRT (ID 13366)

      16:45 - 18:00  |  Author(s): Wei Yang

      • Abstract
      • Slides


      Radiation pneumonitis is a potentially fatal complication in lung cancer patients treated with definitive radiotherapy. The ability to identify patients at risk for this complication would be of value to clinicians. The objective of this study was to identify significant predictors of grade 2 or higher radiation pneumonitis. Previous reported studies mostly focused on extended-field three-dimensional conformal radiotherapy without image guided. The purpose of the study was to correlate clinical and dosimetric factors with the development of radiation pneumonitis in patients with lung cancer treated with involved-field image guided intensity modulated radiation therapy (IMRT).

      a9ded1e5ce5d75814730bb4caaf49419 Method

      149 lung cancer patients treated with involved-field image guided IMRT were recruited. Potential predictive factors examined included age, gender, histology, stage, pulmonary function, KPS, radiation dose, surgery history, usage of chemotherapy. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ≥ 2. Univariate and mutivariate analysis was used to determine predictors of grade 2 or higher pneumonitis.

      4c3880bb027f159e801041b1021e88e8 Result

      Of the 149 patients, Median prescription dose was 60Gy. With a median follow-up of 9 months, 10 cases (6.7%) developed RP of grade 3 or higher level, 57 (38.3%) developed RP of grade ≥ 2 RP, and 90 (62.7%) of grade 1 or lower level. The median time of grade ≥ 2 RP was 2.6 months (range from 1 to 6 months). Grade ≥ 2 RP pneumonitis was correlated with age and volume of lung receiving 20 Gy (V20). Surgery had a bordline significant association with risk of grade≥ 2 RP pneumonitis.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Age and V20 were significant predictors of grade≥2RP radiation pneumonitis in lung cancer patient treated with involved-field image guided IMRT, Surgery also had a bordline significant predictive value.


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