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Lehui Du
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P1.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 949)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 2
- Moderators:
- Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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P1.17-03 - Potential Associated SNPs by GWAS with Radiation Pneumonitis (RP) in Patients with Lung Cancer Treated with Radiotherapy (ID 13305)
16:45 - 18:00 | Presenting Author(s): Lehui Du
- Abstract
Background
Lung cancer is one of the most prevalent cancers and the leading cause of cancer-related deaths in China and worldwide. Radiation therapy plays a remarkable role in lung cancer treatment, and approximately 60%~70% lung cancer patients receive radiation treatment. Whereas, radiation pneumonitis is one of the most critical dose-limiting toxicities of thoracic radiation. Single nucleotide polymorphisms (SNPs) in inflammation-related, DNA repair-related, oxidative stress response-related and angiogenesis-related genes and so on were proved to be associated with RP, with different underlying mechanisms. Previous limited studies reported few SNP sites that may be used a biomarker for prediction of RP risk. However these studies mainly focused on previously reported sites and only limited sites were tested. Here, the purpose of this study was to evaluate the potential related SNPs by whole genome sequencing and radiation pneumonitis (RP) development.
a9ded1e5ce5d75814730bb4caaf49419 Method
We recruited a total of 132 patients with lung cancer receiving intensity modulated radiation therapy (IMRT). We collected the blood sample and sequenced the whole genomes in all patients. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ≥ 2. Genomes-Wide Association Study (GWAS) was carried out to look for potential SNPs associated with risk of RP grade ≥ 2.
4c3880bb027f159e801041b1021e88e8 Result
The incidence of RP of grade ≥ 2 was 29.2%. Using SNP information by Genomes-Wide Association Study (GWAS), we discovered 73 SNPs that showed significant difference with cutting off p-value of 0.001. Most of them are previously not reported.
8eea62084ca7e541d918e823422bd82e Conclusion
This result established a set of biomarkers which can be used for prognosis predictions for radiation-induced pneumonitis.
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P1.17-19 - Correlation of Dosimetric and Clinical Factors with Radiation Pneumonitis in Lung Cancer Patients Received Involved-Field IMRT (ID 13366)
16:45 - 18:00 | Presenting Author(s): Lehui Du
- Abstract
Background
Radiation pneumonitis is a potentially fatal complication in lung cancer patients treated with definitive radiotherapy. The ability to identify patients at risk for this complication would be of value to clinicians. The objective of this study was to identify significant predictors of grade 2 or higher radiation pneumonitis. Previous reported studies mostly focused on extended-field three-dimensional conformal radiotherapy without image guided. The purpose of the study was to correlate clinical and dosimetric factors with the development of radiation pneumonitis in patients with lung cancer treated with involved-field image guided intensity modulated radiation therapy (IMRT).
a9ded1e5ce5d75814730bb4caaf49419 Method
149 lung cancer patients treated with involved-field image guided IMRT were recruited. Potential predictive factors examined included age, gender, histology, stage, pulmonary function, KPS, radiation dose, surgery history, usage of chemotherapy. RP events were prospectively scored using the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE), version 4.0. Kaplan-Meier analysis was used to determine the cumulative probability of RP of grade ≥ 2. Univariate and mutivariate analysis was used to determine predictors of grade 2 or higher pneumonitis.
4c3880bb027f159e801041b1021e88e8 Result
Of the 149 patients, Median prescription dose was 60Gy. With a median follow-up of 9 months, 10 cases (6.7%) developed RP of grade 3 or higher level, 57 (38.3%) developed RP of grade ≥ 2 RP, and 90 (62.7%) of grade 1 or lower level. The median time of grade ≥ 2 RP was 2.6 months (range from 1 to 6 months). Grade ≥ 2 RP pneumonitis was correlated with age and volume of lung receiving 20 Gy (V20). Surgery had a bordline significant association with risk of grade≥ 2 RP pneumonitis.
8eea62084ca7e541d918e823422bd82e Conclusion
Age and V20 were significant predictors of grade≥2RP radiation pneumonitis in lung cancer patient treated with involved-field image guided IMRT, Surgery also had a bordline significant predictive value.
6f8b794f3246b0c1e1780bb4d4d5dc53
