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Koji Yamazaki



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    P1.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 948)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.16-56 - Prognostic Ability of New T1 Descriptors in the TNM Classification of Surgically Treated Non-Small Cell Lung Cancer (ID 12857)

      16:45 - 18:00  |  Author(s): Koji Yamazaki

      • Abstract
      • Slides

      Background

      In the tumor, node, and metastasis (TNM) classification (8th edition) of non-small cell lung cancer (NSCLC), T (tumor size) is determined solely according to the size of the solid component determined using computed tomography (CT). However, it is unclear if tumors of equal size but with differing solid and part-solid components should be similarly treated. Here we assessed the prognostic significance of the newly proposed T1 descriptors with respect to the size of the solid component.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We analyzed overall survival (OS) and disease-free survival (DFS) between groups of patients (n = 255) with solid or part-solid tumors. Propensity score matching (PSM) was added as an exploratory analysis of survival among patients with solid tumors and part-solid tumors to balance the size of the solid. The new staging system was used for classification and comparison of survival.

      4c3880bb027f159e801041b1021e88e8 Result

      figure.jpgChest CT detected 7 non-solid tumors, 123 part-solid tumors and 125 solid tumors. All patients underwent pulmonary lobectomy. The 5-year OS and DFS rates differed significantly between the solid tumor (OS, 71.2%; DFS, 65.4%) and part-solid tumor (OS, 83.2%; DFS, 78.2%) groups. However, among 81 PSM pairs, their 5-year survival rates did not significantly differ as follows: 5-year OS, solid tumor group = 75.1% vs part-solid group = 79.6% (P=0.39); and 5-year DFS, solid tumor group = 68.2% vs part-solid group = 71.9% (P=0.37). Using the 8th TNM edition, 5-year OS rates were patients diagnosed with cIA1 disease: 88.0%; cIA2: 79.4%; and cIA3: 67.6%.

      8eea62084ca7e541d918e823422bd82e Conclusion

      PSM did not detect a significant difference in survival between the groups with solid tumors and those with part-solid tumors when matched according to the size of the solid component. The new T descriptors included in the 8th edition of the TNM provide a detailed classification of patients with NSCLC ≤3 cm in diameter.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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