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Chuanmiao Xie



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    P1.16 - Treatment of Early Stage/Localized Disease (Not CME Accredited Session) (ID 948)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.16-40 - Evaluating the Tumor Heterogeneity in Lung Cancer by Constructing Tumor Heterogeneity Index (THI) from Magnetic Resonance Imaging (ID 13134)

      16:45 - 18:00  |  Author(s): Chuanmiao Xie

      • Abstract

      Background

      To improve the evaluation of primary lung cancer heterogeneity using clinical routine magnetic resonance imaging (MRI), we proposed a method based on basic measurements from T1- and T2-weighted MRI.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      As a novel technique of magnetic resonance imaging analysis, we investigated a total of 203 patients with biopsy-proven primary lung cancer and with different T stages. All patients previously received positron emission tomography/computed tomography (PET/CT) scan. Gross lesions were manually contoured on T1-weighted, T1-enhanced, T2-weighted and T2 fat suppression (T2fs) images. The ratios of standard deviation (SD) / mean tumor value from each sequence were calculated. Correlation analyses were performed between T stages and the ratios. P value <0.05 was defined as statistical significant. Then a linear regression was performed to determine the weight of each related ratio. A model was built to calculate Tumor Heterogeneous Index (THI). One hundred and one patients were analyzed as the training set and another 102 as validating set.

      4c3880bb027f159e801041b1021e88e8 Result

      There were 56 patients diagnosed with T1 disease, 60 with T2 disease, 51 with T3 disease and 36 with T4 disease. Pair matching was performed between training set and validating set. As a result of the correlation analyses, SD/mean ratio showed significantly correlations with T stages in T1-enhanced (p=0.003), T2-weighted (p<0.0001) and T2fs sequences (p=0.002). Based on a linear regression model, THI was established for assessing the heterogeneity of lung tumor, consisting the three ratio measurements. Correlation analysis demonstrated that Higher THI was significantly related to more advanced T stages (p<0.0001).

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      8eea62084ca7e541d918e823422bd82e Conclusion

      The proposed SD/mean ratio measurements and the calculation of THI according to clinical routine MR images could be clinical biomarkers that correlated with T stages, and were capable of evaluating heterogeneity of lung cancers.

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    P3.17 - Treatment of Locoregional Disease - NSCLC (Not CME Accredited Session) (ID 983)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/26/2018, 12:00 - 13:30, Exhibit Hall
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      P3.17-08 - Assessing Primary Lung Cancer Lesion Using Ratio Metrics of T1 and T2-Weighted Images in Magnetic Resonance Imaging (ID 13151)

      12:00 - 13:30  |  Author(s): Chuanmiao Xie

      • Abstract

      Background

      To assess if ratio metrics of T1-weighted (T1w) and T2-weighted (T2w) images in magnetic resonance imaging (MRI) could serve as a sensitive marker to improve the diagnostic efficacies of primary pulmonary lesions with reference to T stages in lung cancer patients.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      Based on the ratio of T1- and T2-weighted signal intensities, we studied a large cohort of NSCLC patients with different T stages using a novel magnetic resonance imaging analysis technique. A total of 101 patients with PET/CT scan and biopsy-proven primary lung lesions were investigated. Gross pulmonary lesions were manually contoured, and corresponding tumor SUVmax, tumor T1-weighted (T1w)/T2-weighted (T2w) intensity ratio, tumor T1-enhanced (T1C)/T2w intensity ratio, muscle T1w/T2w intensity ratio and muscleT1C/T2w intensity ratio had been measured and correlated with T stages.

      4c3880bb027f159e801041b1021e88e8 Result

      There were 25 patients with T1 disease, 29 with T2 disease, 27 with T3 disease and 20 with T4 disease. All the 101 lung lesions were SUV avid, MRI imaging and (18)F-FDG PET/CT agreed on T stages in all patients (100%). Median SUVmax were 12.4 in T1, 12.4 in T2, 12.9 in T3 and 13.0 in T4 patients, respectively. Patients showed lower T1/T2w ratio values in tumor while higher T1/T2w ratio in muscle area (median tumorT1/T2w ratio: 0.69, median muscleT1/T2w ratio: 2.45, P=0.000). In contrast enhanced MRI, a higher T1C/T2w ratio was observed in tumor as compared to T1/T2w ratio (median tumorT1/T2w ratio: 0.69, median tumorT1C/T2w ratio: 2.45, P=0.000). However, tumor T1Cw/T2w ratio was still lower than muscle T1C/T2w ratio (median tumorT1C/T2w ratio: 2.45, median muscleT1C/T2w ratio: 3.25, P=0.000).

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      8eea62084ca7e541d918e823422bd82e Conclusion

      The T1/T2-weighted ratio can improve diagnostic efficacies of primary pulmonary lesions that match hypermetabolic tissues in PET/CT and enables more detailed tissue characterization of lung cancers.

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