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Marju Kase

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    P1.15 - Treatment in the Real World - Support, Survivorship, Systems Research (Not CME Accredited Session) (ID 947)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.15-11 - Lung Cancer as One of Multiple Cancers: A Population-Based Study in Estonia 1995-2015 (ID 13660)

      16:45 - 18:00  |  Author(s): Marju Kase

      • Abstract


      Due to recent developments in cancer prevention, early diagnosis and treatment, more cancers are detected at earlier stages and more patients are cured. As a result, the burden of second and further primary malignancies in a growing and ageing population has remarkably increased over the last decades. Lung cancer is one of the most frequent but most deadly types of cancer. Whether this type of malignancy has a considerable role among multiple cancers is not known. Therefore, the aim of the present study was to assess lung cancer cases as one of the multiple cancers in Estonia.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      We used the data from the Estonian Cancer Registry (ECR), a population-based registry with nationwide coverage (total 1.3 million inhabitants). The ECR provided data on all lung cancer cases and associated multiple cancer cases diagnosed in Estonia 1995‒2015.

      4c3880bb027f159e801041b1021e88e8 Result

      During the time period of 20 years, 146541 cancer cases (ICD-10 C00-C97 and in situ cancers D00-D09) were recorded. Lung cancer cases (n=16350) comprised 11% of all malignancies. Out of all diagnosed lung cancer cases, 10% of patients had multiple cancers (n=1619). Lung cancer as first multiple cancer was diagnosed in 398 patients (25%; 338 men, 60 women; median age 67 years, range 31-87 years). Lung cancer as second cancer was diagnosed in 1130 patients (70%; 851 men, 279 women; median age 67 years, range 32-91 years). Ninety one patients had lung cancer as their third cancer (5%; 67 men, 24 women; median age 66 years, range 32-79 years). None of the patients had lung cancer as fourth or further multiple cancers. Next to lung cancer, patients had mostly melanoma and other malignant tumors of skin (18%), malignant neoplasms of digestive organs (18%), male genital organs (18%) and urinary tract (13%) as well as respiratory tract cancers including new lung primaries (10%). Other types of cancers represented 23% of malignancies. After first diagnosis of lung cancer, second tumor was diagnosed approximately 5 months (median) later. As second multiple cancer, lung cancer was diagnosed 7 years (median) after the first cancer diagnosis. Lung cancer as third cancer developed approximately 2 years (median) after the second diagnosis of malignant tumor.

      8eea62084ca7e541d918e823422bd82e Conclusion

      Multiple cancers are common among lung cancer patients in Estonia. Particular attention is needed, when patient with lung cancer develops skin changes, gastrointestinal and genitourinary symptoms or presents with newly developed respiratory tract complaints.