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Hsien-Chi John Liao



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    P1.14 - Thymoma/Other Thoracic Malignancies (Not CME Accredited Session) (ID 946)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.14-05 - The Association of Pulmonary Function with Survival After Treatment in Patients with Esophageal Cancer (ID 12098)

      16:45 - 18:00  |  Presenting Author(s): Hsien-Chi John Liao

      • Abstract
      • Slides

      Background

      Previously studies have found that inadequate pulmonary function of the patients with esophageal cancer can associate with higher risk of postoperative pulmonary complications which can lead to a higher risk of mortality in the perioperative period or long term follow-up. In this study, we investigate the prognostic effect of pulmonary function for the patients of esophageal cancer after treatment.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      From 2004~2016, 732 esophageal cancer patients underwent surgical treatment were enrolled. They received pulmonary function before treatment, and 542 (74.04%) underwent pre-operative concurrent chemoradiotherapy (CCRT) before surgery. Patients were divided into three groups by pulmonary function level (FEV<80%, inadequate pulmonary function; 80% < FEV1 < 100%, adequate pulmonary function; FEV1 > 100%, well pulmonary function). We use multivariate analysis including all of the possible factors to evaluate overall survival and progression-free survival after surgery.

      4c3880bb027f159e801041b1021e88e8 Result

      As the result, we found that cancer staging, neo-adjuvant CCRT, operation method and pre-operative FEV1 were found statistically significant for survival after treatment. As compared to patients with FEV1 less than 80% of prediction, patients with EFV1 more than 80% had an around thirty percent of decreasing mortality rate after surgery (p = 0.034). The cox-regression with survival analysis also revealed that patients with better lung function, had significantly better progression-free survival (P<0.05, respectively) than those with poor lung function. Besides, the grouping by CCRT-pCR (pathologic complete response) also had similar results. It maybe due to pulmonary function is a important immunological factor in those esophageal cancer patients.

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      8eea62084ca7e541d918e823422bd82e Conclusion

      Although the patient selection, surgical technique, and other postoperative management have been markedly improved in recent years, the morbidity rate after esophagectomy for esophageal cancer remains high. Recent studies lead us pay attention to the perioperative and postoperative care, but they may ignored the pulmonary function disturbance is one of the major contributing factor for long-term and progression-free survival.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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