Author of

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  P1.09 - Pathology (Not CME Accredited Session) (ID 941)

  • Event: WCLC 2018
  • Type: Poster Viewing in the Exhibit Hall
  • Track:
  • Presentations: 1
  • Moderators:
  • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall

  • 26543

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    P1.09-39 - Spread Through Air Spaces Predicts a Worse Survival in Patients with Stage I Adenocarcinomas > 2.0cm After Radical Lobectomy (ID 11202)

    16:45 - 18:00  |  Presenting Author(s): Lin Yang
    • Abstract
    • Slides

    Background
    

    Spread through air spaces (STAS) has been reported a predictor for recurrence or metastasis for lung cancer patients after limited resection, however, the significance of STAS for patients with lobectomy remains inconsistent. The aim of this study was to evaluate the significance of Spread Through Air Spaces (STAS) in early lung adenocarcinomas after radical lobectomy and lymphadenectomy.

    a9ded1e5ce5d75814730bb4caaf49419 Method
    

    A total of 242 patients with lung adenocarcinomas less than 4cm (8^th pStage I) were selected from the lung cancer patients surgically treated from January, 2009 to September, 2011. Pathological review focused on STAS, and recurrence or distant metastasis-free survival(DFS) and overall survival(OS) were compared between patients as stratified by STAS and tumor size.

    4c3880bb027f159e801041b1021e88e8 Result
    

    STAS was observed in 33.47%(81/242) patients, which was significantly correlated with histological predominant subtype (χ2=25.903, p=0.000) and differentiation grade(χ2=23.986, p=0.000).Patients with STAS (+) showed a comparable PFS(p=0.268) and OS rates(p=0.100) in all stage I cases, but a significant lower PFS(p=0.029) and OS(p=0.013) in tumors within 2.1~4.0cm. Multivariate analysis revealed STAS to be an independent worse prognostic factor in lung adenocarcinomas within 2.1~4.0cm, both for PFS(p=0.004) and OS(p=0.002) , while no significant difference was found in patients with tumors≤2.0cm(PFS, p=0.537; OS, p=0.448), after adjusting by other clinicopathological parameters as age, gender, smoking etc.

    8eea62084ca7e541d918e823422bd82e Conclusion
    

    Presence of STAS was a significant worse predictor for pStage I patients with lung adenocarcinoma>2.0cm who underwent radical lobectomy, while it is not significant in patients with tumor ≤2.0cm. These findings may be helpful in assessing postoperative therapy stratified by tumor size and STAS status.

    6f8b794f3246b0c1e1780bb4d4d5dc53

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