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Takeshi Fujii

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    P1.09 - Pathology (Not CME Accredited Session) (ID 941)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.09-37 - Tumor Spread Through Air Spaces (STAS) in Stage I Lung Squamous Cell (ID 12094)

      16:45 - 18:00  |  Author(s): Takeshi Fujii

      • Abstract
      • Slides


      Tumor spread through air spaces (STAS) has been reported as a form of tumor invasion having an unfavorable prognosis mainly in small lung adenocarcinomas, but the significance of STAS in lung squamous cell carcinomas is not well known. The aim of this study was to analysis STAS in stage I lung squamous cell carcinomas.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      39 completely surgically resected (lobectomy) stage I lung squamous cell carcinomas from 2005 to 2009 were included in this study. We examined all tumor edges to find floating tumor cells or clusters, STAS. A statistical analysis was performed to determine the impact of clinicopathologic parameters on STAS and to clarify the relationship between STAS and patient survival.

      4c3880bb027f159e801041b1021e88e8 Result

      STAS was present in 18 of 39 cases (46.2%). There were no statistically significant associations between STAS and any clinicopathologic parameters including stage and lymph-vascular invasions. There was a significant association between presence of STAS and shorter recurrence-free survival (RFS) in univariate analysis (104.7 months with STAS, 145.5 months without STAS). In a multivariate Cox proportional hazards model, STAS (p=0.06) couldn’t reach a significant predictor of RFS.

      8eea62084ca7e541d918e823422bd82e Conclusion

      We found STAS about in half of resected stage I lung squamous cell carcinomas. Presence of STAS was predictive factor of worse RFS in univariate analysis, but not significant in multivariate analysis.


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