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Andreas Karameris



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    P1.09 - Pathology (Not CME Accredited Session) (ID 941)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.09-35 - Clinical Impact of Systematic Inflammation and Histologic Grade in Non Small Cell Lung Carcinoma (NSCLC) (ID 14389)

      16:45 - 18:00  |  Author(s): Andreas Karameris

      • Abstract
      • Slides

      Background

      Tumor grade is an important factor of cancer outcome. Systematic inflammation has been associated with tumorigenesis and tumor aggressiveness and prognosis in several human malignancies. Cancer cells create an inflammatory peritumoral microenviroment by releasing a number of cytokines.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      In total, 100 patients (88 males) with histologically proven NSCLC and no signs of active infection were evaluated. Tumor grade was examined and systematic inflammatory response was assessed by circulating levels of C-reactive protein (CRP), albumin, ferritin, transferring and the modified Glasgow Prognostic Score (mGPS). Patients were followed up and survival data were subsequently collected. Associations with clinicopathological, histological parameters and patients’ survival were studied.

      4c3880bb027f159e801041b1021e88e8 Result

      Histological grade was associated with tumor size, the presence of pathological lymph nodes, organ metastases and advanced disease stage (p=0.010, p<0.001, p<0.001 and p<0.001, respectively). There was a trend of higher histological grade in adenocarcinomas compared to squamous carcinomas (p=0.263). High tumor histological grade was also significantly associated with elevated serum CRP levels (p<0.001), hypoalbuminemia (p=0.009), elevated ferritin levels (p=0.049), abnormal mGPS (p=0.006) and a trend for reduced transferrin levels (p=0.101). In multivariate analysis, histological grade, stage, ECOG performance status and mGPS were identified as independent prognostic factors for overall survival (Cox regression analysis, p=0.002, p=0.001, p=0.010 and p=0.019, respectively).

      8eea62084ca7e541d918e823422bd82e Conclusion

      Our data support the association of tumour grade with the presence of systemic inflammation; two well described negative prognostic factors for NSCLC. To our knowledge this is the first time that these factors are associated with each other giving more information about the prognosis in patients with NSCLC.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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