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Feyyaz Ozdemir



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    P1.09 - Pathology (Not CME Accredited Session) (ID 941)

    • Event: WCLC 2018
    • Type: Poster Viewing in the Exhibit Hall
    • Track:
    • Presentations: 1
    • Moderators:
    • Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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      P1.09-24 - The Effects of NLR and PLR of Effect on Prognosis in Patients with the Lung Cancer (ID 11912)

      16:45 - 18:00  |  Author(s): Feyyaz Ozdemir

      • Abstract
      • Slides

      Background

      Inflammation has an important role in the pathogenesis of cancer. Platelet/Lymphocyte (PLR) and Neutrophil/Lymphocyte ratios (NLR) are known as parameters that indicate the status of inflammation and can be used in determining the prognosis of cancer. The object of this study is to investigate the effect of the preoperative NLR and PLR on disease-free (DFS) and overall survival (OS) in patients with lung cancer.

      a9ded1e5ce5d75814730bb4caaf49419 Method

      In this study, 68 patients, who underwent surgery and received a diagnosis of lung cancer between 2004 and 2014 were evaluated retrospectively. Date of diagnosis, demographic characteristics, tumor stage and location, vascular invasion status, perineural invasion status, lymph node involvement, histological type, grade, adjuvant treatment status, preoperative neutrophils, lymphocytes and platellet number were analyzed. Preoperative PLR and NLR computed and median value of these rates were determined. The Kaplan-Meier method was used for DFS and OS analysis of patients who were above or below the median. Confidence interval and statistically significant p-value was considered respectively %95 , <0.05.

      4c3880bb027f159e801041b1021e88e8 Result

      68 patients, 7 were female and 61 male, mean age was 57. 23 of 68 patients Stage1, 33 patients Stage 2, 12 patients and Stage 3. Histopathological analyse performed, and the end of analyse; 48,5% adenocarcinoma, 42,6% squamous cell carcinoma 8,9% other types were watched. Average PLR and average NLR was seen as respectively 120 and 2,2. DFS (47.3 months versus 50.8 months) was shorter in lung cancer patients with high NLR, but OS was longer (82.3 months versus 78.2). DFS (42.8 months versus 55.4 months) was shorter in lung cancer patients with high PLR and OS was longer (84.5 months versus 76.7 months). The difference between the two groups was not statistically significant.

      8eea62084ca7e541d918e823422bd82e Conclusion

      The effect of high NLR and PLR on DFS and OS in patients with lung cancer was not statistically significant. Prognostic value of NLR and PLR before treatment is not clearly demonstrated, and extensive prospective studies should be performed with multiple centers and more patient.

      6f8b794f3246b0c1e1780bb4d4d5dc53

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