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Elanur Karaman
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P1.09 - Pathology (Not CME Accredited Session) (ID 941)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/24/2018, 16:45 - 18:00, Exhibit Hall
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P1.09-24 - The Effects of NLR and PLR of Effect on Prognosis in Patients with the Lung Cancer (ID 11912)
16:45 - 18:00 | Author(s): Elanur Karaman
- Abstract
Background
Inflammation has an important role in the pathogenesis of cancer. Platelet/Lymphocyte (PLR) and Neutrophil/Lymphocyte ratios (NLR) are known as parameters that indicate the status of inflammation and can be used in determining the prognosis of cancer. The object of this study is to investigate the effect of the preoperative NLR and PLR on disease-free (DFS) and overall survival (OS) in patients with lung cancer.
a9ded1e5ce5d75814730bb4caaf49419 Method
In this study, 68 patients, who underwent surgery and received a diagnosis of lung cancer between 2004 and 2014 were evaluated retrospectively. Date of diagnosis, demographic characteristics, tumor stage and location, vascular invasion status, perineural invasion status, lymph node involvement, histological type, grade, adjuvant treatment status, preoperative neutrophils, lymphocytes and platellet number were analyzed. Preoperative PLR and NLR computed and median value of these rates were determined. The Kaplan-Meier method was used for DFS and OS analysis of patients who were above or below the median. Confidence interval and statistically significant p-value was considered respectively %95 , <0.05.
4c3880bb027f159e801041b1021e88e8 Result
68 patients, 7 were female and 61 male, mean age was 57. 23 of 68 patients Stage1, 33 patients Stage 2, 12 patients and Stage 3. Histopathological analyse performed, and the end of analyse; 48,5% adenocarcinoma, 42,6% squamous cell carcinoma 8,9% other types were watched. Average PLR and average NLR was seen as respectively 120 and 2,2. DFS (47.3 months versus 50.8 months) was shorter in lung cancer patients with high NLR, but OS was longer (82.3 months versus 78.2). DFS (42.8 months versus 55.4 months) was shorter in lung cancer patients with high PLR and OS was longer (84.5 months versus 76.7 months). The difference between the two groups was not statistically significant.
8eea62084ca7e541d918e823422bd82e Conclusion
The effect of high NLR and PLR on DFS and OS in patients with lung cancer was not statistically significant. Prognostic value of NLR and PLR before treatment is not clearly demonstrated, and extensive prospective studies should be performed with multiple centers and more patient.
6f8b794f3246b0c1e1780bb4d4d5dc53
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P2.10 - Prevention and Tobacco Control (Not CME Accredited Session) (ID 959)
- Event: WCLC 2018
- Type: Poster Viewing in the Exhibit Hall
- Track:
- Presentations: 1
- Moderators:
- Coordinates: 9/25/2018, 16:45 - 18:00, Exhibit Hall
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P2.10-14 - The Evalution of Relationship Between Radon Gas and Lung Cancers in Trabzon (ID 11911)
16:45 - 18:00 | Author(s): Elanur Karaman
- Abstract
Background
Radon is a carcinogenic gas and the second most important cause of lung cancer after tobacco smoking. The object of this study is to evaluate the relationship between lung cancer patients in Trabzon province according to the districts and the radon gas exposures with the floor number of the patients resident.
a9ded1e5ce5d75814730bb4caaf49419 Method
A total of 104 patients, who were diagnosed with lung cancer living in the province of Trabzon, included to this retrospective study. Spearman Correlation test was used to evaluate the correlation between radon gas and the incidence of lung cancer according to the Trabzon districts.
4c3880bb027f159e801041b1021e88e8 Result
The highest incidence of lung cancer was found with 32.3/100.000 in 2016 and the highest concentration of radon gas was 132 Bq/m3 in Trabzon.There was no statistically significant correlation between radon gas concentrations and lung cancer incidence in Trabzon districts (p=0.446, r=-0.076). We found a low negative correlation between the radon gas level and the floor number of the patients reside in. This difference was statistically significant (r=-0.259, p=0.008).This result was supportive the relationship between high radon gas concentration and lung cancer.
8eea62084ca7e541d918e823422bd82e Conclusion
Radon gas constitutes about 50% of natural radiation. A statistically significant difference was found between radon gas level and the floor number of the patients resident in Trabzon. There is needed to undertake more extensive studies on this subject throughout Turkey.
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